Exercise and GLUT4

被引:59
作者
Flores-Opazo, Marcelo [1 ]
McGee, Sean L. [2 ,3 ]
Hargreaves, Mark [4 ]
机构
[1] Univ Finis Terrae, Dept Physiotherapy, Lab Exercise & Phys Act Sci, Santiago, Chile
[2] Deakin Univ, Sch Med, Metab Res Unit, Waurn Ponds, Australia
[3] Deakin Univ, Inst Mental & Phys Hlth & Clin Translat IMPACT, Waurn Ponds, Australia
[4] Univ Melbourne, Dept Physiol, Grattan St, Melbourne, Vic 3010, Australia
来源
EXERCISE AND SPORT SCIENCES REVIEWS | 2020年 / 48卷 / 03期
基金
英国医学研究理事会;
关键词
exercise; GLUT4; insulin sensitivity; skeletal muscle; muscle; glucose; HUMAN SKELETAL-MUSCLE; STIMULATED GLUCOSE-TRANSPORT; ACTIVATED PROTEIN-KINASE; MYOCYTE ENHANCER FACTOR-2; INSULIN ACTION; ENDURANCE EXERCISE; INDUCED INCREASE; MESSENGER-RNA; NITRIC-OXIDE; ADIPOSE-TISSUE;
D O I
10.1249/JES.0000000000000224
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The glucose transporter GLUT4 is critical for skeletal muscle glucose uptake in response to insulin and muscle contraction/exercise. Exercise increases GLUT4 translocation to the sarcolemma and t-tubule and, over the longer term, total GLUT4 protein content. Here, we review key aspects of GLUT4 biology in relation to exercise, with a focus on exercise-induced GLUT4 translocation, postexercise metabolism and muscle insulin sensitivity, and exercise effects on GLUT4 expression.
引用
收藏
页码:110 / 118
页数:9
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