Exercise and GLUT4

被引：57

作者：

Flores-Opazo, Marcelo ^{[1
]}

McGee, Sean L. ^{[2
,3
]}

Hargreaves, Mark ^{[4
]}

机构：

[1] Univ Finis Terrae, Dept Physiotherapy, Lab Exercise & Phys Act Sci, Santiago, Chile

[2] Deakin Univ, Sch Med, Metab Res Unit, Waurn Ponds, Australia

[3] Deakin Univ, Inst Mental & Phys Hlth & Clin Translat IMPACT, Waurn Ponds, Australia

[4] Univ Melbourne, Dept Physiol, Grattan St, Melbourne, Vic 3010, Australia

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2020年 / 48卷 / 03期

基金：

英国医学研究理事会;

关键词：

exercise; GLUT4; insulin sensitivity; skeletal muscle; muscle; glucose; HUMAN SKELETAL-MUSCLE; STIMULATED GLUCOSE-TRANSPORT; ACTIVATED PROTEIN-KINASE; MYOCYTE ENHANCER FACTOR-2; INSULIN ACTION; ENDURANCE EXERCISE; INDUCED INCREASE; MESSENGER-RNA; NITRIC-OXIDE; ADIPOSE-TISSUE;

D O I：

10.1249/JES.0000000000000224

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The glucose transporter GLUT4 is critical for skeletal muscle glucose uptake in response to insulin and muscle contraction/exercise. Exercise increases GLUT4 translocation to the sarcolemma and t-tubule and, over the longer term, total GLUT4 protein content. Here, we review key aspects of GLUT4 biology in relation to exercise, with a focus on exercise-induced GLUT4 translocation, postexercise metabolism and muscle insulin sensitivity, and exercise effects on GLUT4 expression.

引用

页码：110 / 118

页数：9

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