A micro-fluidic sub-microliter sample introduction system for direct analysis of Chinese rice wine by inductively coupled plasma mass spectrometry using external aqueous calibration

被引:16
作者
Cheng, Heyong [1 ,2 ]
Liu, Jinhua [2 ]
Xu, Zigang [3 ]
Yin, Xuefeng [1 ,2 ]
机构
[1] Zhejiang Univ, Inst Microanalyt Syst, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China
[2] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 310036, Zhejiang, Peoples R China
[3] Zhejiang Univ, Inst Analyt & Appl Chem, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China
基金
中国国家自然科学基金;
关键词
Microfluidic; Sub-microliter sample; Inductively coupled plasma mass spectrometry; Direct analysis; Chinese rice wine; MATRIX METALLOPROTEINASE-2; YELLOW WINE; DESOLVATION; NEBULIZER; TOXICITY; MS;
D O I
10.1016/j.sab.2012.07.010
中图分类号
O433 [光谱学];
学科分类号
0703 ; 070302 ;
摘要
A microfluidic sub-microliter sample introducing system was developed for direct analysis of Chinese rice wine by inductively coupled plasma mass spectrometry (ICP-MS). It consisted of a microfluidic chip integrating variable-volume sampling channels (0.1-0.8 mu L), an eight-way multi-functional valve used in flow injection analysis (FIA), a syringe pump and a peristaltic pump of the Ar ICP-MS instrument. Three solutions, Le., 15, 40 and 100 g L-1 glucose in 20% ethanol were used to simulate Chinese rice wine of the dry type, the semidry type and the semisweet type, each. The effects of their volume introduced into ICP-MS on the plasma stability and ICP-MS intensities were studied. The experimental results showed that neither alteration of plasma stability nor carbon deposition was observed when the sampling volume of 20% ethanol containing 100 g L-1 glucose was downscaled to 0.8 mu L. Further reducing the sampling volume to 0.4 mu L, no significant difference between the intensities of multi-element standard prepared in three simulated Chinese rice wine matrices and those in aqueous solution was observed. It indicated no negative effect of Chinese rice wine matrix on the ICP-MS intensities. A sampling volume of 0.4 mu L was considered to be a good compromise between sensitivity and matrix effect. The flow rate of the carrier was chosen as 20 mu L min(-1) for obtaining peaks with the highest peak height within the shortest time. Based on these observations, a microflow injection (mu FI) method for the direct determination of cadmium and lead in Chinese rice wine by ICP-MS using an external aqueous calibration was developed. The sample throughput was 45 h(-1) with the detection limit of 19.8 and 10.4 ng L-1 for Cd and Pb, respectively. The contents of Cd and Pb in 10 Chinese rice wine samples were measured. The results agreed well with those determined by ICP-MS with the conventional sampling system after microwave assisted digestion. The recoveries of three Chinese rice wine samples ranged between 95.5 and 102.8%. Furthermore, the determined contents of Cd and Pb in a certified reference material of red wine (GBW 10031) and a quality control test material of wine (PAPAS T07163QC) by the proposed method were in fairly good accordance with the certified/assigned values. All results verified the accuracy of our method. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:55 / 61
页数:7
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