Graft-vs-Host Disease Following Allogeneic Hematopoietic Cell Transplantation

被引:40
|
作者
Pidala, Joseph [1 ,2 ]
机构
[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Blood & Marrow Transplant Program, Tampa, FL 33612 USA
[2] Univ S Florida, Coll Med, Dept Oncol Sci, Tampa, FL USA
关键词
CONSENSUS DEVELOPMENT PROJECT; BONE-MARROW-TRANSPLANTATION; WORKING GROUP-REPORT; UNRELATED DONOR TRANSPLANTATION; CORD BLOOD TRANSPLANTATION; BARR-VIRUS REACTIVATION; ANTI-THYMOCYTE GLOBULIN; HIGH-RISK PATIENTS; CD4(+) T-CELLS; CLINICAL-TRIALS;
D O I
10.1177/107327481101800407
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative therapy with proven efficacy in the management of hematologic malignancies. However, it is complicated by the syndromes of acute and chronic graft-vs-host disease (GVHD). Methods: A narrative review is provided to summarize major biologic insights into the pathogenesis of these immune-mediated disorders, as well as advances in diagnosis, classification, prevention, management, and allied supportive care with the aim of providing essential understanding for clinicians with or without subspecialty experience in the field of blood and marrow transplantation. Results: Major scientific advances have contributed to enhanced understanding of the pathogenesis of these disorders, and clinical investigation has provided more effective preventive and therapeutic strategies for GVHD. However, since acute GVHD and chronic GVHD remain leading sources of transplantation-related morbidity and mortality, ongoing investigation is needed to develop new approaches to addressing these syndromes. Conclusions: The major challenge for future investigation will be to capitalize on biologic insights in order to develop novel strategies for the prevention and therapy of acute and chronic GVHD that will address the current shortcomings in existing therapeutic approaches.
引用
收藏
页码:268 / 276
页数:9
相关论文
共 50 条
  • [21] Does defibrotide prophylaxis decrease the risk of acute graft versus host disease following allogeneic hematopoietic cell transplantation?
    Tekgunduz, Emre
    Kaya, Ali Hakan
    Bozdag, Sinem Civriz
    Kocubaba, Erife
    Kayikci, Omur
    Namdaroglu, Sinem
    Ugur, Bilge
    Akpinar, Seval
    Batgi, Hikmetullah
    Bekdemir, Filiz
    Altuntas, Fevzi
    TRANSFUSION AND APHERESIS SCIENCE, 2016, 54 (01) : 30 - 34
  • [22] Relationship Between HLA Tissue Type, CMV Infection, and Acute Graft-vs-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation: Single-Center Experience
    Kekik, C.
    Besisik, S. K.
    Seyhun, Y.
    Oguz, F. S.
    Sargin, D.
    Carin, M. N.
    TRANSPLANTATION PROCEEDINGS, 2009, 41 (09) : 3859 - 3862
  • [23] A reappraisal of the histopathologic criteria for the diagnosis of cutaneous allogeneic acute graft-vs-host disease
    Massi, D
    Franchi, A
    Pimpinelli, N
    Laszlo, D
    Bosi, A
    Santucci, M
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1999, 112 (06) : 791 - 800
  • [24] New Strategy of Acute Graft-vs-Host Disease: Investigation of a Reduced Dose of Antithymocyte Globulin in Haploidentical Hematopoietic Stem Cell Transplantation
    Sun, Y.
    Wei, C.
    Cao, C.
    Tan, X.
    Zeng, H.
    Luo, Y.
    Chen, L.
    TRANSPLANTATION PROCEEDINGS, 2019, 51 (03) : 890 - 895
  • [25] Erosive Tarsal Conjunctival Lesions Following Immunogenic Events in Early Development of Ocular Graft-vs-Host Disease
    Kohnstam, Marcus G.
    Surico, Pier Luigi
    Luo, Zhonghui K.
    LIFE-BASEL, 2024, 14 (10):
  • [26] Decoding Skin Involvement in Chronic Graft-vs-Host Disease
    Cowen, Edward W.
    JAMA DERMATOLOGY, 2019, 155 (07) : 777 - 778
  • [27] Global Metabolomics in Allogeneic Hematopoietic Cell Transplantation Recipients Discordant for Chronic Graft-versus-Host Disease
    Kelly, Debra Lynch
    Farhadfar, Nosha
    Starkweather, Angela
    Garrett, Timothy J.
    Yao, Yingwei
    Wingard, John R.
    Mahmud, Iqbal
    Menzies, Victoria
    Patel, Param
    Alabasi, Karima M.
    Lyon, Debra
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2020, 26 (10) : 1803 - 1810
  • [28] Dermoscopy of Cutaneous Graft-Versus-Host-Disease in Patients After Allogeneic Hematopoietic Stem Cell Transplantation
    Kaminska-Winciorek, Grazyna
    Zalaudek, Iris
    Mendrek, Wlodzimierz
    Jaworska, Magdalena
    Gajda, Maksymilian
    Holowiecki, Jerzy
    Szymszal, Jan
    Giebel, Sebastian
    DERMATOLOGY AND THERAPY, 2020, 10 (05) : 1043 - 1061
  • [29] Muscle Cramps and Neuropathies in Patients with Allogeneic Hematopoietic Stem Cell Transplantation and Graft-versus-Host Disease
    Kraus, Peter D.
    Wolff, Daniel
    Grauer, Oliver
    Angstwurm, Klemens
    Jarius, Sven
    Wandinger, Klaus P.
    Holler, Ernst
    Schulte-Mattler, Wilhelm
    Kleiter, Ingo
    PLOS ONE, 2012, 7 (09):
  • [30] Diagnostic and Prognostic Biomarkers for Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation
    Kalariya, Nilesh
    Bowe, Christi
    Dains, Joyce E.
    ONCOLOGY NURSING FORUM, 2020, 47 (02) : E35 - E43