Protein Interactions on Telomeric Retrotransposons in Drosophila

被引：9

作者：

Takacs, Sandor ^{[1
]}

Biessmann, Harald ^{[3
]}

Reddy, Hemakumar M. ^{[2
]}

Mason, James M. ^{[2
]}

Torok, Tibor ^{[1
]}

机构：

[1] Univ Szeged, Dept Genet, H-6701 Szeged, Hungary

[2] NIEHS, Mol Genet Lab, Res Triangle Pk, NC 27709 USA

[3] Univ Calif Irvine, Ctr Dev Biol, Irvine, CA 92697 USA

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2012年 / 8卷 / 07期

关键词：

chromatin; Chromator; prod; putzig; Z4; sumoylation; telomere; Drosophila; retrotransposon; DISTINCT CHROMATIN DOMAINS; PROLIFERATION-DISRUPTER; CHROMODOMAIN PROTEIN; MELANOGASTER; KINASE; ELONGATION; LENGTH; PROD; ENDS; TEL;

D O I：

10.7150/ijbs.4460

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomere length in Drosophila is maintained by targeted transposition of three non-LTR retrotransposons: HeT-A, TART and TAHRE (HTT), but understanding the regulation of this process is hindered by our poor knowledge of HTT associated proteins. We have identified new protein components of the HTT array: Chromator (Chro), the TRF2/DREF complex and the sumoylation machinery. Chro was localized on telomeric HTT arrays by immunostaining, where it may interact with Prod directly, as indicated by yeast two-hybrid interaction, co-IP, and colocalization on polytene chromosomes. The TRF2/DREF complex may promote the open structure of HTT chromatin. The protein interactions controlling HTT chromatin structure and telomere length may be modulated by sumoylation.

引用

收藏

页码：1055 / 1061

页数：7

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