Giving the right tug for migration: Cadherins in tissue movements

被引:19
作者
Becker, Sarah F. [1 ]
Langhe, Rahul [1 ]
Huang, Chaolie [1 ]
Wedlich, Doris [1 ]
Kashef, Jubin [1 ]
机构
[1] KIT Campus S, Inst Zool, Dept Cell & Dev Biol, D-76131 Karlsruhe, Germany
关键词
Neural crest migration; Gastrulation; Convergent extension; Epiboly; Optic/otic vesicle formation; PCP signaling; NEURAL CREST MIGRATION; BREAST-CANCER CELLS; XENOPUS PARAXIAL PROTOCADHERIN; CANDIDATE TUMOR-SUPPRESSOR; GLASS-ONION LOCUS; N-CADHERIN; BETA-CATENIN; CONVERGENT EXTENSION; VE-CADHERIN; ALPHA-CATENIN;
D O I
10.1016/j.abb.2012.02.013
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Dynamically regulated cell-cell adhesion is crucial for morphogenesis during embryonic development and tumor progression. The cadherins as calcium-dependent cell-cell adhesion proteins represent key molecules in these tissue movements. How cadherins serve in maintaining tissue cohesion during migration, facilitate cell-cell communication and promote signaling will be summarized in this review. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码:30 / 42
页数:13
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