Interleukin-32: A predominantly intracellular proinflammatory mediator that controls cell activation and cell death

被引：57
作者：
Heinhuis, Bas [1 ,2 ]
Netea, Mihai G. [1 ,3 ]
van den Berg, Wim B. [2 ]
Dinarello, Charles A. [1 ,4 ]
Joosten, Leo A. B. [1 ,3 ]
机构：
[1] Radboud Univ Nijmegen, Dept Med, Med Ctr, NL-6500 HB Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Dept Rheumatol, NL-6500 HB Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Med Ctr, Nijmegen Inst Infect Inflammat & Immun N4i, NL-6500 HB Nijmegen, Netherlands
[4] Univ Colorado Denver, Div Infect Dis, Aurora, CO 80045 USA
来源：
CYTOKINE | 2012年 / 60卷 / 02期
关键词：
Cytokines; IL-32; Inflammation; Cell death; Autoimmune diseases; RNA INTERFERENCE; IL-32; CYTOKINE; DIFFERENTIATION; INFLAMMATION; ALPHA; RGD; IL-32-GAMMA; EXPRESSION; IL-1-BETA;
D O I：
10.1016/j.cyto.2012.07.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this review, we will discuss the current knowledge on IL-32 and provide new insights regarding the biological function of IL-32. IL-32 is seen as a cytokine that can induce a range of proinflammatory mediators and contribute to autoimmune diseases, such as rheumatoid arthritis, however present knowledge demonstrates that IL-32 is not a classical cytokine. We present the history of this cytokine, the role of IL-32 in several diseases and discuss a possible novel role of intracellular IL-32 in cell homeostasis. Taken into account the observed biological functions of IL-32, it may belong to a class of cytokines, like IL-1 alpha, IL-33, and IL-37, with both intracellular and extracellular functions. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：321 / 327
页数：7
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