Interleukin-32: A predominantly intracellular proinflammatory mediator that controls cell activation and cell death

被引：57
作者：
Heinhuis, Bas [1 ,2 ]
Netea, Mihai G. [1 ,3 ]
van den Berg, Wim B. [2 ]
Dinarello, Charles A. [1 ,4 ]
Joosten, Leo A. B. [1 ,3 ]
机构：
[1] Radboud Univ Nijmegen, Dept Med, Med Ctr, NL-6500 HB Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Dept Rheumatol, NL-6500 HB Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Med Ctr, Nijmegen Inst Infect Inflammat & Immun N4i, NL-6500 HB Nijmegen, Netherlands
[4] Univ Colorado Denver, Div Infect Dis, Aurora, CO 80045 USA
来源：
CYTOKINE | 2012年 / 60卷 / 02期
关键词：
Cytokines; IL-32; Inflammation; Cell death; Autoimmune diseases; RNA INTERFERENCE; IL-32; CYTOKINE; DIFFERENTIATION; INFLAMMATION; ALPHA; RGD; IL-32-GAMMA; EXPRESSION; IL-1-BETA;
D O I：
10.1016/j.cyto.2012.07.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this review, we will discuss the current knowledge on IL-32 and provide new insights regarding the biological function of IL-32. IL-32 is seen as a cytokine that can induce a range of proinflammatory mediators and contribute to autoimmune diseases, such as rheumatoid arthritis, however present knowledge demonstrates that IL-32 is not a classical cytokine. We present the history of this cytokine, the role of IL-32 in several diseases and discuss a possible novel role of intracellular IL-32 in cell homeostasis. Taken into account the observed biological functions of IL-32, it may belong to a class of cytokines, like IL-1 alpha, IL-33, and IL-37, with both intracellular and extracellular functions. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：321 / 327
页数：7
相关论文
共 64 条
[31]   The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors [J].
Kawai, Taro ;
Akira, Shizuo .
NATURE IMMUNOLOGY, 2010, 11 (05) :373-384
[32]   Interleukin-32:: A cytokine and inducer of TNFα [J].
Kim, SH ;
Han, SY ;
Azam, T ;
Yoon, DY ;
Dinarello, CA .
IMMUNITY, 2005, 22 (01) :131-142
[33]   Effect of Interleukin-32γ on Differentiation of Osteoclasts From CD14+Monocytes [J].
Kim, Yong-Gil ;
Lee, Chang-Keun ;
Oh, Ji Seon ;
Kim, Soo-Hyun ;
Kim, Kyoung-A ;
Yoo, Bin .
ARTHRITIS AND RHEUMATISM, 2010, 62 (02) :515-523
[34]   Interleukin-32β Propagates Vascular Inflammation and Exacerbates Sepsis in a Mouse Model [J].
Kobayashi, Hanako ;
Huang, Jianhua ;
Ye, Fei ;
Shyr, Yu ;
Blackwell, Timothy S. ;
Lin, P. Charles .
PLOS ONE, 2010, 5 (03)
[35]   INTERLEUKIN-32 POSITIVELY REGULATES RADIATION-INDUCED VASCULAR INFLAMMATION [J].
Kobayashi, Hanako ;
Yazlovitskaya, Eugenia M. ;
Lin, P. Charles .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2009, 74 (05) :1573-1579
[36]   Molecular characterization of IL-32 in human endothelial cells [J].
Kobayashi, Hanako ;
Lin, P. Charles .
CYTOKINE, 2009, 46 (03) :351-358
[37]   IL-32: A Host Proinflammatory Factor against Influenza Viral Replication Is Upregulated by Aberrant Epigenetic Modifications during Influenza A Virus Infection [J].
Li, Wei ;
Sun, Wei ;
Liu, Li ;
Yang, Fang ;
Li, Yongkui ;
Chen, Yanni ;
Fang, Jiali ;
Zhang, Wenjing ;
Wu, Jianguo ;
Zhu, Ying .
JOURNAL OF IMMUNOLOGY, 2010, 185 (09) :5056-5065
[38]   Activation of Interleukin-32 Pro-Inflammatory Pathway in Response to Influenza A Virus Infection [J].
Li, Wei ;
Liu, Yan ;
Mukhtar, Muhammad Mahmood ;
Gong, Rui ;
Pan, Ying ;
Rasool, Sahibzada T. ;
Gao, Yecheng ;
Kang, Lei ;
Hao, Qian ;
Peng, Guiqing ;
Chen, Yanni ;
Chen, Xin ;
Wu, Jianguo ;
Zhu, Ying .
PLOS ONE, 2008, 3 (04)
[39]   Interleukin-32 Promotes Osteoclast Differentiation but Not Osteoclast Activation [J].
Mabilleau, Guillaume ;
Sabokbar, Afsie .
PLOS ONE, 2009, 4 (01)
[40]   MicroRNA-205-Directed Transcriptional Activation of Tumor Suppressor Genes in Prostate Cancer [J].
Majid, Shahana ;
Dar, Altaf A. ;
Saini, Sharanjot ;
Yamamura, Soichiro ;
Hirata, Hiroshi ;
Tanaka, Yuichiro ;
Deng, Guoren ;
Dahiya, Rajvir .
CANCER, 2010, 116 (24) :5637-5649
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