Interleukin-32: A predominantly intracellular proinflammatory mediator that controls cell activation and cell death

被引：57
作者：
Heinhuis, Bas [1 ,2 ]
Netea, Mihai G. [1 ,3 ]
van den Berg, Wim B. [2 ]
Dinarello, Charles A. [1 ,4 ]
Joosten, Leo A. B. [1 ,3 ]
机构：
[1] Radboud Univ Nijmegen, Dept Med, Med Ctr, NL-6500 HB Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Dept Rheumatol, NL-6500 HB Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Med Ctr, Nijmegen Inst Infect Inflammat & Immun N4i, NL-6500 HB Nijmegen, Netherlands
[4] Univ Colorado Denver, Div Infect Dis, Aurora, CO 80045 USA
来源：
CYTOKINE | 2012年 / 60卷 / 02期
关键词：
Cytokines; IL-32; Inflammation; Cell death; Autoimmune diseases; RNA INTERFERENCE; IL-32; CYTOKINE; DIFFERENTIATION; INFLAMMATION; ALPHA; RGD; IL-32-GAMMA; EXPRESSION; IL-1-BETA;
D O I：
10.1016/j.cyto.2012.07.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this review, we will discuss the current knowledge on IL-32 and provide new insights regarding the biological function of IL-32. IL-32 is seen as a cytokine that can induce a range of proinflammatory mediators and contribute to autoimmune diseases, such as rheumatoid arthritis, however present knowledge demonstrates that IL-32 is not a classical cytokine. We present the history of this cytokine, the role of IL-32 in several diseases and discuss a possible novel role of intracellular IL-32 in cell homeostasis. Taken into account the observed biological functions of IL-32, it may belong to a class of cytokines, like IL-1 alpha, IL-33, and IL-37, with both intracellular and extracellular functions. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：321 / 327
页数：7
相关论文
共 64 条
[1]   The Ins and Outs of Leukocyte Integrin Signaling [J].
Abram, Clare L. ;
Lowell, Clifford A. .
ANNUAL REVIEW OF IMMUNOLOGY, 2009, 27 :339-362
[2]   Innate immunity triggers IL-32 expression by fibroblast-like synoviocytes in rheumatoid arthritis [J].
Alsaleh, Ghada ;
Sparsa, Laetitia ;
Chatelus, Emmanuel ;
Ehlinger, Mathieu ;
Gottenberg, Jacques-Eric ;
Wachsmann, Dominique ;
Sibilia, Jean .
ARTHRITIS RESEARCH & THERAPY, 2010, 12 (04)
[3]  
[Anonymous], ARTHRITIS RHEUM
[4]   IL-32 Is a Host Protective Cytokine against Mycobacterium tuberculosis in Differentiated THP-1 Human Macrophages [J].
Bai, Xiyuan ;
Kim, Soo-Hyun ;
Azam, Tania ;
McGibney, Mischa T. ;
Huang, Hua ;
Dinarello, Charles A. ;
Chan, Edward D. .
JOURNAL OF IMMUNOLOGY, 2010, 184 (07) :3830-3840
[5]   Effects of treatment with a fully human anti-tumour necrosis factor α monoclonal antibody on the local and systemic homeostasis of interleukin 1 and TNFα in patients with rheumatoid arthritis [J].
Barrera, P ;
Joosten, LAB ;
den Broeder, AA ;
van de Putte, LBA ;
van Riel, PLCM ;
van den Berg, WB .
ANNALS OF THE RHEUMATIC DISEASES, 2001, 60 (07) :660-669
[6]   Evidence that cytokines play a role in rheumatoid arthritis [J].
Brennan, Fionula M. ;
McInnes, Iain B. .
JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (11) :3537-3545
[7]   RGD peptides induce apoptosis by direct caspase-3 activation [J].
Buckley, CD ;
Pilling, D ;
Henriquez, NV ;
Parsonage, G ;
Threlfall, K ;
Scheel-Toellner, D ;
Simmons, DL ;
Albar, AN ;
Lord, JM ;
Salmon, M .
NATURE, 1999, 397 (6719) :534-539
[8]  
Cagnard N, 2005, EUR CYTOKINE NETW, V16, P289
[9]   IL-32, a Novel Proinflammatory Cytokine in Chronic Obstructive Pulmonary Disease [J].
Calabrese, Fiorella ;
Baraldo, Simonetta ;
Bazzan, Erica ;
Lunardi, Francesca ;
Rea, Federico ;
Maestrelli, Piero ;
Turato, Graziella ;
Lokar-Oliani, Kim ;
Papi, Alberto ;
Zuin, Renzo ;
Sfriso, Paolo ;
Balestro, Elisabetta ;
Dinarello, Charles A. ;
Saetta, Marina .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2008, 178 (09) :894-901
[10]   Overexpression of IL-32α Increases Natural Killer Cell-mediated Killing through Up-regulation of Fas and UL16-binding protein 2 (ULBP2) Expression in Human Chronic Myeloid Leukemia Cells [J].
Cheon, Soyoung ;
Lee, Ji Hyung ;
Park, Sunyoung ;
Bang, Sa Ik ;
Lee, Wang Jae ;
Yoon, Do-Young ;
Yoon, Sung-Soo ;
Kim, Taesung ;
Min, Hyeyoung ;
Cho, Byung Joo ;
Lee, Hyong Joo ;
Lee, Ki Woong ;
Jeong, Seung Hwan ;
Park, Hyunjeong ;
Cho, Daeho .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (14) :12049-12055
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