A convenient synthesis of highly substituted 2-pyridones

被引：23

作者：

Collins, I ^{[1
]}

Castro, JL ^{[1
]}

机构：

[1] Merck Sharp & Dohme Ltd, Neurosci Res Ctr, Res Lab, Dept Med Chem, Harlow CM20 2QR, Essex, England

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 21期

关键词：

pyridones; coupling reactions; Vilsmeier reactions reagents;

D O I：

10.1016/S0040-4039(99)00651-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rapid and convenient synthesis of the 3-trifluoromethanesulfonyloxy-2-pyridone 2, one of the first examples of this class of compound, was achieved by Vilsmeier formylation and cyclisation of the acyl enamine 6. The triflate 2 was found to undergo a range of palladium-catalysed coupling reactions giving a synthetic sequence of general use for the preparation of highly substituted 2-pyridones. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4069 / 4072

页数：4

共 25 条

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