Update 1 of: Synthesis and Functionalization of Indoles Through Palladium-Catalyzed Reactions

被引：662

作者：

Cacchi, Sandro ^{[1
]}

Fabrizi, Giancarlo ^{[1
]}

机构：

[1] Univ Rome, Dipartimento Chim & Technol Farmaco, I-00185 Rome, Italy

来源：

CHEMICAL REVIEWS | 2011年 / 111卷

关键词：

CROSS-COUPLING REACTIONS; SOLID-PHASE SYNTHESIS; ONE-POT SYNTHESIS; HETEROAROMATIC RING-SYSTEMS; DIRECT C-2 ARYLATION; DIRECTED ORTHO-METALATION; EFFICIENT TOTAL-SYNTHESIS; CARBON BOND FORMATION; ASSISTED INTRAMOLECULAR AMINATION; ENANTIOSPECIFIC TOTAL-SYNTHESIS;

D O I：

10.1021/cr100403z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A team of scientists has made an effort to provide a comprehensive and updated overview of the latest developments in the palladium-catalyzed approaches to the preparation of indole derivatives with the emphasis on the rationale behind each synthetic procedure and the dependence of the results on a proper selection of reaction conditions. Palladium-catalyzed reactions are strongly dependent on a number of factors, such as the nature of stabilizing ligands, bases, additives, the combination of them, solvents, and temperature. All of these factors combine to afford a toolbox of tunable reaction conditions that make palladium chemistry so and unpredictable, providing an opportunity for an uninterrupted discovery of new, exciting chemistry despite the vast amount of studies.

引用

页码：PR215 / PR283

页数：69

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