Polymeric micelle stability

被引：768

作者：

Owen, Shawn C. ^{[1
,2
]}

Chan, Dianna P. Y.

Shoichet, Molly S. ^{[1
,2
,3
]}

机构：

[1] Univ Toronto, Dept Chem Engn & Appl Chem, Shoichets Lab, Toronto, ON M5S 3E1, Canada

[2] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3E1, Canada

[3] Univ Toronto, Dept Chem, Toronto, ON M5S 3E1, Canada

来源：

NANO TODAY | 2012年 / 7卷 / 01期

关键词：

Micelle; Stability; Nanoparticles; Drug delivery; Polymer; BLOCK-COPOLYMER MICELLES; DRUG-DELIVERY; DIBLOCK COPOLYMERS; POLY(ETHYLENE OXIDE); CLINICAL-TRIAL; NANOPARTICLES; RELAXATION; KINETICS; CARRIERS; RELEASE;

D O I：

10.1016/j.nantod.2012.01.002

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polymeric micelles provide a platform that can be carefully tuned for drug delivery. The nano-scale aggregates form spontaneously in aqueous solution and can be used to overcome drug insolubility and increase circulation half life. Self-assembled polymeric micelles are dynamic in nature; thermodynamics defines how the system acts as micelles approach equilibrium, while kinetics characterizes the system's behavior over time. In this review, we discuss factors that affect the stability of self-assembled polymeric micelle systems for drug delivery and methods used to study stability. Considerations of polymer composition, drug encapsulation, and environmental conditions influence polymeric micelle stability. Ultimately, we emphasize the importance of investigating micelle systems in physiologically relevant media to improve therapeutic efficacy and reduce systemic toxicity in clinical applications. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：53 / 65

页数：13

共 99 条

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