Synthesis, radiometal labeling and in vitro evaluation of a targeted PPIX derivative

被引：26

作者：

Azad, Babak Behnam ^{[2
]}

Cho, Choi-Fong ^{[3
]}

Lewis, John D. ^{[1
,3
,4
,5
]}

Luyt, Leonard G. ^{[1
,2
,4
,6
]}

机构：

[1] London Reg Canc Program, London, ON N6A 4L6, Canada

[2] Univ Western Ontario, Dept Chem, London, ON N6A 5B7, Canada

[3] Univ Western Ontario, Dept Med Biophys, London, ON N6A 5B7, Canada

[4] Univ Western Ontario, Dept Oncol, London, ON N6A 5B7, Canada

[5] Univ Western Ontario, Dept Surg, London, ON N6A 5B7, Canada

[6] Univ Western Ontario, Dept Med Imaging, London, ON N6A 5B7, Canada

来源：

APPLIED RADIATION AND ISOTOPES | 2012年 / 70卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Molecular imaging; PPIX; Gallium-68; Metal conjugates; Fluorescence microscopy; Radiolabeling; PHOTODYNAMIC THERAPY; ALPHA(V)BETA(3) INTEGRIN; CLINICAL-SIGNIFICANCE; PROTOPORPHYRIN-IX; EXPRESSION; FLUORESCENCE; PHOTOSENSITIZER; PORPHYRINS; COMPLEXES; MELANOMA;

D O I：

10.1016/j.apradiso.2011.11.054

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In pursuit of a single molecule with potential applications for both in vitro fluorescence microscopy and in vivo PET imaging, novel targeted Ga-69/71/Ga-68-protoporphyrin IX (PPIX) probes were developed. Optical analysis, fluorescence microscopy and radiolabeling with gallium-68 were performed to confirm potential applications. The use of a targeted-PPIX ring, in conjunction with Ga-69/71 or Ca-68, eliminates the need for the attachment of multiple imaging tags, allowing for either in vitro fluorescent-based evaluation or in vivo nuclear-based imaging. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：505 / 511

页数：7

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