Nonlinearity in DNA and its Relation to Specific Functions

被引：5
作者：
Alexandrov, Boian [1 ]
Rasmussen, Kim O. [1 ]
Bishop, Alan R. [1 ]
机构：
[1] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM 87545 USA
来源：
JOURNAL OF BIOLOGICAL PHYSICS | 2009年 / 35卷 / 01期
关键词：
Nonlinear dynamics of DNA; DNA modeling; STATISTICAL-MECHANICS; UNZIPPING DNA; DYNAMICS; COOPERATIVITY; TRANSCRIPTION; DENATURATION; OLIGOMERS; SOLITONS; MODEL;
D O I：
10.1007/s10867-009-9125-4
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
In memory of Alwyn Scott, we discuss the connection between the nonlinear dynamics of double-stranded DNA, experimental findings, and specific DNA functions. We begin by discussing how thermally induced localized openings (bubbles) of the DNA double-strand are important for interpreting dynamic force spectroscopy data. Then, we demonstrate a correlation between the sequence-dependent propensity for bubble formation and transcription initiation and other regulatory effects in viral DNA. Finally, we discuss the possibility of a connection between DNA dynamics and the ability of repair proteins to recognize ultraviolet-radiation damage.
引用
收藏
页码：31 / 41
页数：11
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