Probiotic Therapy for Treating Behavioral and Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review of Clinical Trials

被引：29
作者：
Liu, Jun [1 ]
Wan, Guo-bing [2 ]
Huang, Ming-shi [2 ]
Agyapong, George [1 ]
Zou, Tian-le [3 ]
Zhang, Xue-ying [4 ]
Liu, Yen-Wenn [5 ]
Song, Yi-qing [6 ]
Tsai, Ying-Chieh [5 ]
Kong, Xue-jun [7 ]
机构：
[1] Harvard Med Sch, Boston, MA 02115 USA
[2] Women & Childrens Hosp, Shenzhen 518052, Peoples R China
[3] NYU, Buffalo, NY 14214 USA
[4] Icahn Sch Med Mt Sinai, New York, NY 10029 USA
[5] Natl Yang Ming Univ, Taipei 112, Taiwan
[6] Indiana Univ, Indianapolis, IN 46202 USA
[7] Massachusetts Gen Hosp, Charlestown, MA 02129 USA
来源：
CURRENT MEDICAL SCIENCE | 2019年 / 39卷 / 02期
关键词：
autism spectrum disorder; probiotics; systematic review; CHILDREN; MICROBIOME; PREVALENCE;
D O I：
10.1007/s11596-019-2016-4
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The therapeutic potentials of probiotics in autism spectrum disorder (ASD) remains controversial, with the only existing systematic review on this topic published in 2015. Results from new trials have become available in recent years. We therefore conducted an updated systematic review, to assess the efficacy of probiotics in relieving behavioral symptoms of ASD and gastrointestinal comorbidities. Our review includes two randomized controlled trials, which showed improvement of ASD behaviors, and three open trials, all which exhibited a trend of improvement. Four of these trials concluded from subjective measures that gastrointestinal function indices showed a trend of improvement with probiotic therapy. Additional rigorous trials are needed to evaluate the effects of probiotic supplements in ASD.
引用
收藏
页码：173 / 184
页数：12
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