The impact of APOE on myocardial infarction, stroke, and dementia - The Rotterdam Study

被引：39

作者：

Slooter, AJC

Cruts, M

Hofman, A

Koudstaal, PJ

van der Kuip, D

de Ridder, MAJ

Witteman, JCM

Breteler, MMB

Van Broeckhoven, C

van Duijn, CM

机构：

[1] Erasmus Med Ctr, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands

[2] Univ Antwerp UIA VIB, Genet Mol Lab, Dept Biochem, Antwerp, Belgium

[3] Univ Med Ctr, Dept Neurol, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands

来源：

NEUROLOGY | 2004年 / 62卷 / 07期

关键词：

D O I：

10.1212/01.WNL.0000118302.66674.E1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

It is unclear how the APOE genotype contributes to the incidence of vascular diseases and dementia. In a population-based sample (n=6,852) with complete follow-up, APOE was weakly associated with myocardial infarction and not related with stroke. In the absence of epsilon4, the incidence of dementia would be 25.8% lower; in the absence of epsilon2/epsilon3, 2.8% higher. Risk estimates of dementia, specified for age, sex, and APOE, are provided for counseling. APOE is not strongly related to vascular diseases, but contributes substantially to dementia incidence.

引用

收藏

页码：1196 / 1198

页数：3

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