Central but not peripheral glucoprivation is impaired in monosodium glutamate-treated rats

被引:4
|
作者
de Andrade, IS
Gonzalez, JCG
Hirata, AE
Carneiro, G
Amado, D
Cavalheiro, EA
Dolnikoff, MS
机构
[1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Physiol, Div Neurophysiol & Endocrine Physiol, BR-04023060 Sao Paulo, Brazil
[2] Univ Fed Sao Paulo, Escola Paulista Med, Dept Neurol & Neurosurg, Div Expt Neurol, BR-04023060 Sao Paulo, Brazil
关键词
2-deoxy-D-glucose; food intake; monosodium glutamate; norepinephrine; plasma free fatty acids; hyperglycemia;
D O I
10.1016/j.neulet.2005.12.043
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In the present study, newborn male Wistar rats were injected, subcutaneously, five times, every other day, with monosodium glutamate (MSG, 4 g/kg bw) or saline (as control, C), during the neonatal period. MSG animals developed destruction of the arcuate nuclei (ARC) with absence of NPY-immunoreactive cell bodies, which impaired both the food intake (baseline) and the 2-deoxy-D-glucose (2DG) glucoprivic feeding response. Increases in the immunoreactivity of corticotropin-releasing hormone-cell bodies in the paraventricular nuclei might have developed to compensate for the atrophy of the pituitary in MSG-treated rats. After systemic 2DG injection, neither the C nor the MSG rats increased their food intake, but they showed similar hyperglycemic responses, whereas plasma free fatty acids (FFA) increased only in the C group. In other groups, 2DG, norepinephrine (NE), neostigmine (NEO) and saline were intracerebroventricularly (i.c.v.) administered. In this condition, impairment of the hyperglycemic and food intake responses, associated to a lower increase in plasma FFA levels, were observed. As opposed to this, the MSG treatment gives support to NE effects, enhancing food intake, as well as plasma glucose and FFA levels. After NEO, plasma glucose increased only in the MSG group, while plasma FFA levels were elevated in the C rats. Taken together, the results obtained after MSG treatment point to a separate neural control of the hyperglycemic response and of the lipid mobilization when stimulated by central 2DG, NE or NEO administration. It seems likely that the excitatory neural pathway that controls lipid metabolism and is present in C rats was destroyed by the MSG treatment. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:6 / 11
页数:6
相关论文
共 50 条
  • [31] Morphological study of pancreas in monosodium glutamate neonataly treated rats
    Rancic, I
    Vujic, Stevan
    Sibinovic, Dejan
    EUROPEAN JOURNAL OF MEDICAL RESEARCH, 2009, 14 : 36 - 36
  • [32] AREA POSTREMA AND ANGIOTENSIN-II PRESSOR DEFICITS IN GLUTAMATE-TREATED RATS
    HARTLE, DK
    SOLIMAN, A
    GEIGER, D
    FASEB JOURNAL, 1988, 2 (05): : A1486 - A1486
  • [33] Dental growth in female rats treated with monosodium glutamate.
    Pinato, L
    Mello, ATS
    Hadaya, A
    Grigolato, EN
    Castro, JCB
    Castro, MTBB
    JOURNAL OF DENTAL RESEARCH, 1996, 75 (05) : 1081 - 1081
  • [34] ADRENALECTOMY PREVENTS OBESITY IN GLUTAMATE-TREATED MICE
    TOKUYAMA, K
    HIMMSHAGEN, J
    AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (02): : E139 - E144
  • [35] Changes in hippocampal synaptic functions and protein expression in monosodium glutamate-treated obese mice during development of glucose intolerance
    Sasaki-Hamada, Sachie
    Hojo, Yuki
    Koyama, Hajime
    Otsuka, Hayuma
    Oka, Jun-Ichiro
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2015, 41 (11) : 1393 - 1401
  • [36] ASSESSMENT OF COLD INDUCED ALTERATIONS IN CATECHOLAMINE TURNOVER OF LEAN AND GLUTAMATE-TREATED OBESE RATS
    ARNDT, T
    REHOREK, A
    MULLER, F
    EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY, 1991, 98 (03): : 207 - 211
  • [37] Loss of weight restores GLUT 4 content in insulin-sensitive tissues of monosodium glutamate-treated obese mice
    PC Papa
    PM Seraphim
    UF Machado
    International Journal of Obesity, 1997, 21 : 1065 - 1070
  • [38] The immunoreactivity of satellite glia of the spinal ganglia of rats treated with monosodium glutamate
    Krawczyk, Aleksandra Ewa
    Jaworska-Adamu, Jadwiga
    ACTA VETERINARIA BRNO, 2016, 85 (04) : 337 - +
  • [39] REDUCTION OF PITUITARY GNRH RECEPTORS IN IMMATURE RATS TREATED WITH MONOSODIUM GLUTAMATE
    DALKIN, AC
    DUNCAN, JA
    REGIANI, S
    MARSHALL, JC
    AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 248 (01): : E126 - E131
  • [40] BEHAVIORAL CHANGES IN ADULT RATS TREATED WITH MONOSODIUM GLUTAMATE IN NEONATAL STAGE
    PRADHAN, SN
    LYNCH, JF
    ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE, 1972, 197 (02): : 301 - &