The brain hypocretins and their receptors: mediators of allostatic arousal

被引：75
作者：
Carter, Matthew E. [1 ]
Borg, Jana Schaich [1 ]
de Lecea, Luis [1 ]
机构：
[1] Stanford Univ, Dept Psychiat & Behav Sci, Palo Alto, CA 94304 USA
来源：
CURRENT OPINION IN PHARMACOLOGY | 2009年 / 9卷 / 01期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
HYPOTHALAMIC OREXIN NEURONS; SLEEP; NARCOLEPSY; STRESS; SYSTEM; REWARD; NEUROPEPTIDE; DISORDER; CIRCUIT; CORTEX;
D O I：
10.1016/j.coph.2008.12.018
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The hypocretins (abbreviated 'Hcrts' - also called 'orexins') are two neuropeptides secreted exclusively by a small population of neurons in the lateral hypothalamus. These peptides bind to two receptors located throughout the brain in nuclei associated with diverse cognitive and physiological functions. Initially, the brain Hcrt system was found to have a major role in the regulation of sleep/wake transitions. More recent studies indicate Hcrts may play a role in other physiological functions, including food intake, addiction, and stress. Taken together, these studies suggest a general role for Hcrts in mediating arousal, especially when an organism must respond to unexpected stressors and challenges in the environment.
引用
收藏
页码：39 / 45
页数：7
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