Prevalence of low serum folate and vitamin B12 in an older Australian population

被引：29

作者：

Flood, VM

Smith, WT

Webb, KL

Rochtchina, E

Anderson, VE

Mitchell, P ^{[1
]}

机构：

[1] Westmead Hosp, Ctr Vis Res, Inst Clin Pathol & Med Res, Westmead, NSW 2145, Australia

[2] Univ Sydney, Dept Publ Hlth, Westmead Millennium Inst, Sydney, NSW 2006, Australia

[3] Univ Sydney, Dept Ophthalmol, Westmead Millennium Inst, Sydney, NSW 2006, Australia

[4] Univ Sydney, Ctr Vis Res, Westmead Millennium Inst, Sydney, NSW 2006, Australia

[5] Univ Sydney, Westmead Millennium Inst, Dept Mol & Microbiol Biosci, Sydney, NSW 2006, Australia

[6] Univ Newcastle, Ctr Clin Epidemiol & Biostat, Newcastle, NSW 2308, Australia

来源：

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH | 2006年 / 30卷 / 01期

关键词：

D O I：

10.1111/j.1467-842X.2006.tb00084.x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objective: To examine the prevalence of low serum folate and vitamin B12, in association with elevated serum homocysteine, in a representative sample of older Australians. Methods: During 1997-2000, 3,508 persons aged 50+ years were examined in a population-based cohort study conducted in two postcodes, west of Sydney, Australia. Of these, 2,901 participants (82.7%) provided fasting blood for estimates of serum folate, vitamin B12 and total homocysteine. Results: Low serum 1312 (< 185 pmoI/L) was found in 22.9% of participants and low serum folate (< 6.8 nmol/L) in 2.3% of participants. Among those people with very low serum vitamin B12 (< 125 pmol/L) and low serum folate, 51% had elevated homocysteine. Conclusions: Low serum levels of vitamin B12 and elevated serum homocysteine are relatively frequent in older Australians. Implications: Appropriate public health action should be considered to reduce the prevalence of low serum vitamin B12 and elevated homocysteine in older Australians.

引用

页码：38 / 41

页数：4

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