Triazolothiadiazoles and triazolothiadiazines - Biologically attractive scaffolds

被引：83
作者：
Khan, Imtiaz [1 ]
Ibrar, Aliya [1 ]
Abbas, Naeem [2 ]
机构：
[1] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan
[2] Univ Gujrat, Dept Chem, Gujrat 50700, Pakistan
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2013年 / 63卷
关键词：
Heterocycles; Inhibitors; Synthesis; Biological activities; IMMUNODEFICIENCY-VIRUS TYPE-1; POSSIBLE ANTICANCER AGENTS; ANTIMICROBIAL ACTIVITIES; PHARMACOLOGICAL-ACTIVITIES; DIHYDRO ANALOGS; DERIVATIVES; ANTIBACTERIAL; BEARING; ACID; 1,2,4-TRIAZOLE;
D O I：
10.1016/j.ejmech.2013.01.060
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Contemporary medicinal chemistry faces diverse challenges from several directions, including the need for both potency and specificity of any therapeutic agent. Therefore, in the present perspective, the triazolothiadiazoles and triazolothiadiazines with broad spectrum biological profile have matured into indispensable heterocyclic scaffolds. This review article is an effort to summarize medicinal chemistry investigations over the last decade, in search for new N-bridged heterocycles which can be a rich source of promising biological activities. (C) 2013 Elsevier Masson SAS. All rights reserved.
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页码：854 / 868
页数：15
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