Fate of selected pharmaceuticals in river waters

被引：38

作者：

Calza, P. ^{[1
]}

Medana, C. ^{[1
]}

Padovano, E. ^{[2
]}

Giancotti, V. ^{[1
]}

Minero, C. ^{[1
]}

机构：

[1] Univ Turin, Dipartimento Chim, I-10125 Turin, Italy

[2] Politecn Torino, Dipartimento Sci Applicata & Tecnol, Turin, Italy

来源：

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH | 2013年 / 20卷 / 04期

关键词：

Carbamazepine; Clarithromycin; Lincomycin; Orbitrap; Intermediates; ITALIAN AQUATIC ENVIRONMENT; TANDEM MASS-SPECTROMETRY; THERAPEUTIC DRUGS; CARBAMAZEPINE; PRODUCTS; METABOLITES; IDENTIFICATION; TRANSFORMATION; PHOTODEGRADATION; CHEMISTRY;

D O I：

10.1007/s11356-012-1097-4

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The aqueous environmental fate of two antibiotics, lincomycin and clarithromycin, and an antiepileptic drug, carbamazepine, was investigated by monitoring drugs decomposition and identifying intermediates in Po river water (North Italy). Initially, control experiments in the dark and under illumination were performed on river water spiked with drugs to simulate all possible transformation processes occurring in the aquatic system. Under illumination, these pharmaceuticals were degraded and transformed into numerous organic intermediate compounds. Several species were formed and characterised by analysing MS and MS (n) spectra and by comparison with parent molecule fragmentation pathways. River water was sampled at three sampling points in an urban area. The selected pharmaceuticals were detected in all samples. Eight transformation products identified in the laboratory simulation were found in natural river water from carbamazepine degradation, three from clarithromycin and two from lincomycin. Their transformation occurring in aquatic system mainly involved mono- and poly-hydroxylation followed by oxidation of the hydroxyl groups.

引用

页码：2262 / 2270

页数：9

共 27 条

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