Palladium-catalyzed carbonylative cyclization of Baylis-Hillman adducts. An efficient approach for the stereoselective synthesis of 3-alkenyl phthalides

被引：50
作者：
Coelho, F
Veronese, D
Pavam, CH
de Paula, VI
Buffon, R
机构：
[1] Univ Estadual Campinas, IQ DQI, BR-13084971 Campinas, SP, Brazil
[2] Lab Synth Nat Prod & Drugs, IQ DQI, BR-13084971 Campinas, SP, Brazil
来源：
TETRAHEDRON | 2006年 / 62卷 / 18期
基金：
巴西圣保罗研究基金会;
关键词：
Baylis-Hillman adducts; phthalides; cyclization; palladium;
D O I：
10.1016/j.tet.2006.02.045
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-mediated carbonylative cyclization reaction of Baylis-Hillman adducts is disclosed. This simple, efficient and straightforward sequence leads to the formation of an array of 3-alkenylphthalides with different substitution patterns on the aromatic ring, with good chemical yields and selectivities. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4563 / 4572
页数：10
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