Myocardial dysfunction during H1N1 influenza infection

被引:54
作者
Fagnoul, David [1 ]
Pasquier, Pierre [1 ]
Bodson, Laurent [1 ]
Ortiz, Julian Arias [1 ]
Vincent, Jean-Louis [1 ]
De Backer, Daniel [1 ]
机构
[1] Univ Libre Brussels, Erasme Univ Hosp, Dept Intens Care, Brussels, Belgium
关键词
Cardiac function; Myocardial depression; Echocardiography; Cardiac output; Oxygen delivery; ARDS; CRITICALLY-ILL PATIENTS; ACUTE COR-PULMONALE; SEPTIC SHOCK; A(H1N1) INFECTION; A H1N1; HEART-FAILURE; VIRUS; HUMANS; PNEUMONIA; SEPSIS;
D O I
10.1016/j.jcrc.2013.01.010
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Purpose: The purpose of the study is to evaluate the incidence and hemodynamic consequences of right ventricular (RV) and left ventricular (LV) dysfunction in critically ill patients with H1N1 infection. Patients and methods: This is a retrospective analysis of all patients admitted to the intensive care unit of an academic hospital between October 2009 and March 2011 with severe H1N1 infection. Hemodynamic measurements and respiratory conditions were noted daily during the intensive care unit stay. Results: Forty-six patients were admitted with severe H1N1 infection. Echocardiography was obtained in 39 patients on admission: 28 (72%) had abnormal ventricular function, of whom 13 (46%) had isolated LV abnormalities, 11 (39%) had isolated RV dysfunction, and 4 (14%) had biventricular dysfunction. Echocardiography was repeated in 19 of the 39 patients during their hospitalization: RV function tended to worsen with time, but LV function tended to normalize. The ventricular abnormalities were not associated with history, severity of the respiratory failure, or hemodynamic status. However, patients with ventricular dysfunction needed more aggressive therapy, including more frequent use of vasopressor and inotropic agents and of rescue ventilatory strategies, such as inhaled nitric oxide, prone positioning, and extracorporeal membrane oxygenation. Conclusions: These observations emphasize the high incidence of cardiac dysfunction in patients with H1N1 influenza infections. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:321 / 327
页数:7
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