Rhodium-catalyzed regio- and enantioselective allylic alkylation of pyrazol-5-ones with alkynes

被引：15

作者：

Ji, Ding-Wei ^{[1
,2
]}

Yang, Fan ^{[1
]}

Chen, Bing-Zhi ^{[1
,2
]}

Min, Xiang-Ting ^{[1
,2
]}

Kuai, Chang-Sheng ^{[1
]}

Hu, Yan-Cheng ^{[1
]}

Chen, Qing-An ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 60期

基金：

中国国家自然科学基金;

关键词：

C-C; PRIMARY ALCOHOLS; TERMINAL ALKYNES; PALLADIUM; ALLYLATION; ACID; REGIOSELECTIVITY; HYDROAMINATION; INDOLES; KETONES;

D O I：

10.1039/d0cc04002a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A rhodium-catalyzed asymmetric allylic alkylation of pyrazol-5-ones with internal alkynes is illustrated. In the presence of a chiral rhodium-hydride catalyst, functionalized heterocyclic products bearing an all-carbon quaternary stereogenic center were obtained in high yields with satisfactory enantioselectivities. This protocol also features good regiocontrol and a high atom economy without stoichiometric by-product formation.

引用

页码：8468 / 8471

页数：4

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