HMGB1 in inflammation and cancer

被引：234
作者：
Wang, Shumin [1 ,2 ,3 ,4 ]
Zhang, Yi [1 ,2 ,3 ,4 ]
机构：
[1] Zhengzhou Univ, Biotherapy Ctr, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China
[2] Zhengzhou Univ, Ctr Canc, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China
[3] Zhengzhou Univ, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Peoples R China
[4] Henan Key Lab Tumor Immunol & Biotherapy, Zhengzhou 450052, Peoples R China
来源：
JOURNAL OF HEMATOLOGY & ONCOLOGY | 2020年 / 13卷 / 01期
关键词：
HMGB1; RAGE; TLR; DAMP; Inflammation; Cancer;
D O I：
10.1186/s13045-020-00950-x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
High mobility group box 1 (HMGB1) is a non-histone chromatin-associated protein widely distributed in eukaryotic cells and is involved in DNA damage repair and genomic stability maintenance. In response to stimulus like bacteria or chemoradiotherapy, HMGB1 can translocate to extracellular context as a danger alarmin, activate the immune response, and participate in the regulation of inflammation and cancer progression.
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页数：4
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