Does Epstein-Barr virus infection have an influence on the development of laryngeal carcinoma? Detection of EBV by Real-Time Polymerase Chain Reaction in tumour tissues of patients with laryngeal carcinoma

被引：11

作者：

Muderris, Tuba ^{[1
]}

Rota, Seyyal ^{[1
]}

Muderris, Togay ^{[2
]}

Inal, Erdogan ^{[2
]}

Fidan, Isil ^{[1
]}

机构：

[1] Gazi Univ, Fac Med, Dept Microbiol, Ankara, Turkey

[2] Gazi Univ, Fac Med, Dept Otolaryngol, Ankara, Turkey

来源：

BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY | 2013年 / 79卷 / 04期

关键词：

Epstein-Barr virus infections; laryngeal neoplasms; polymerase chain reaction; SQUAMOUS-CELL CARCINOMA; HUMAN-PAPILLOMAVIRUS; ORAL CANCERS; PREVALENCE; ASSOCIATION; NECK; HEAD; HYBRIDIZATION; EXPRESSION; LESIONS;

D O I：

10.5935/1808-8694.20130075

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Epstein-Barr virus (EBV) is a well-known carcinogenic virus, and the association of EBV with some tumours suggests that there may also be an association between laryngeal carcinoma and EBV. Objective: The aim of this study is to determine the role of EBV in the aetiology of laryngeal carcinoma. Method: Prospective investigation the EBV with real time polymerase chain reaction in tumour tissues of 25 patients with laryngeal carcinoma and 17 patients with benign laryngeal lesions, and investigation of the relationship between the presence of viral DNA and patients' smoking habits, alcohol consumption, localization and differentiation of the tumour. Results: There was no significant difference between the control group and patient group in terms of EBV polymerase chain reaction positivity (p > 0.05). Also we couldn't find a statistically significant relationship between EBV positivity and differentiation of the tumour, localization of the tumour, smoking and alcohol consumption habits (p > 0.05). Conclusion: Our results suggest that, although EBV is present in some of the squamous cell laryngeal carcinomas, its presence has no effect on the pathogenesis of laryngeal carcinomas.

引用

页码：418 / 423

页数：6

共 32 条

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