Bacterial Protein N-Glycosylation: New Perspectives and Applications

被引：125

作者：

Nothaft, Harald ^{[1
]}

Szymanski, Christine M.

机构：

[1] Univ Alberta, Alberta Glyc Ctr, Edmonton, AB T6G 2E9, Canada

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2013年 / 288卷 / 10期

关键词：

INFLUENZAE HMW1 ADHESIN; GRAM-NEGATIVE BACTERIUM; CAMPYLOBACTER-JEJUNI; LINKED GLYCOSYLATION; ACTINOBACILLUS-PLEUROPNEUMONIAE; FUNCTIONAL-CHARACTERIZATION; SUBSTRATE-SPECIFICITY; NEISSERIA-GONORRHOEAE; GLYCOPROTEIN; GLYCANS;

D O I：

10.1074/jbc.R112.417857

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein glycosylation is widespread throughout all three domains of life. Bacterial protein N-glycosylation and its application to engineering recombinant glycoproteins continue to be actively studied. Here, we focus on advances made in the last 2 years, including the characterization of novel bacterial N-glycosylation pathways, examination of pathway enzymes and evolution, biological roles of protein modification in the native host, and exploitation of the N-glycosylation pathways to create novel vaccines and diagnostics.

引用

页码：6912 / 6920

页数：9

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