Afobazole Restores the Dopamine Level in a 6-Hydroxydopamine Model of Parkinson's Disease

被引：6
作者：
Voronin, M. V. [1 ]
Kadnikov, I. A. [1 ]
Seredenin, S. B. [1 ]
机构：
[1] Zakusov Res Inst Pharmacol, Moscow, Russia
来源：
NEUROCHEMICAL JOURNAL | 2019年 / 13卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
6-hydroxydopamine; afobazole; striatum; monoamines; UNFOLDED PROTEIN RESPONSE; SIGMA-1; RECEPTORS; OXIDATIVE STRESS; MITOCHONDRIAL RESPIRATION; MOLECULAR CHAPERONES; NEUROTROPHIC FACTOR; MOUSE MODEL; EXPRESSION; BINDING; NEURODEGENERATION;
D O I：
10.1134/S1819712419010185
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In this study, 5 mu g of 6-hydroxydopamine (6-OHDA) were injected unilaterally into the striatum of mice. The mice were then treated intraperitoneally with afobazole at a dose of 2.5 mg/kg for 14 days starting 30 min after the 6-OHDA injection. The content of monoamines was studied in the striatum of the mice. Afobazole prevented a decrease in the dopamine level in the 6-OHDA-damaged striatum of the experimental animals and did not affect the contents of norepinephrine, serotonin, or its metabolites in the striatum of both the control and 6-OHDA-treated mice.
引用
收藏
页码：49 / 56
页数：8
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