Pregnancy-associated breast cancer (PABC)

The occurrence of pregnancy-associated breast cancer (PABC) is rare but increasing. Its management is challenging: to treat the patient without compromising fetal prognosis. Usually, PABC is diagnosed at a more advanced stage compared to non-pregnant patients of the same age. The diagnostic approach should fit with the recommendations for nonpregnant women except CT scan or isotopic exploration, which are performed only if absolutely necessary. Similarly, the therapeutic management should be close to guidelines: surgical treatment and sentinel lymph node procedure (without blue patent), chemotherapy beyond the first trimester, and radiotherapy during the 1st and 2nd trimesters. Targeted therapy and hormonal therapy are not recommended during pregnancy. After this treatment, the prognosis of PABC is comparable to nonpregnant patients with similar clinical, histological, and radiological characteristics.