CALCIUM SULFATE LEADS TO OSTEOGENIC DIFFERENTIATION OF ADIPOSE DERIVED STEM CELLS

被引：0
作者：
Brunelli, G. [1 ]
Carinci, F. [2 ]
Girardi, A. [3 ]
Palmieri, A. [2 ]
Caccianiga, G. L. [1 ]
Sollazzo, V. [4 ]
机构：
[1] Don Orione Inst, Dept Dent & Maxillofacial Surg, Bergamo, Italy
[2] Univ Ferrara, Dept DMCCC, Sect Maxillofacial & Plast Surg, I-44100 Ferrara, Italy
[3] Univ Bologna, Dept Histol Embryol & Appl Biol, Bologna, Italy
[4] Univ Ferrara, Orthoped Clin, I-44100 Ferrara, Italy
来源：
EUROPEAN JOURNAL OF INFLAMMATION | 2012年 / 10卷 / 01期
关键词：
Calcium sulfate; adipose tissue; stem cells; gene expression; osteoblast differentiation;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The ideal bone graft material would be biocompatible, completely biodegradable, osteoconductive, unexpensive, easy to handle, and able to support the defect area until bone growth is complete. Several bone graft materials are available, but none of them have thus far satisfied all of these requirements. Calcium sulfate is one of the oldest bone graft materials and possesses good effect on acceletaring bone healing and regeneration. To study the mechanism how CaS can induce differentiation and proliferation in ADSCs the expression levels of several bone related genes were analyzed using real time Reverse Transcription-Polymerase Chain Reaction. Our results show that CaS strongly influences the behavior of ADSCs in vitro by enhancing proliferation, differentiation and deposition of matrix by increasing the activity of RUNX2, SP7 and SPP1.
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页码：17 / 21
页数：5
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