Daytime Secretion of Salivary Cortisol and Alpha-Amylase in Preschool-Aged Children with Autism and Typically Developing Children

被引：37

作者：

Kidd, Sharon A. ^{[1
]}

Corbett, Blythe A. ^{[2
]}

Granger, Douglas A. ^{[3
]}

Boyce, W. Thomas ^{[4
,5
]}

Anders, Thomas F. ^{[2
]}

Tager, Ira B. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA

[2] Univ Calif Davis, Med Ctr, MIND Inst, Sacramento, CA 95817 USA

[3] Penn State Univ, Dept Biobehav Hlth, University Pk, PA 16802 USA

[4] Univ British Columbia, Coll Interdisciplinary Studies, Vancouver, BC V6T 123, Canada

[5] Univ British Columbia, Fac Med, Vancouver, BC V6T 123, Canada

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2012年 / 42卷 / 12期

关键词：

Autism; Children; Salivary cortisol; Salivary alpha-amylase; Diurnal; Variability; DEXAMETHASONE SUPPRESSION TEST; CAUSAL INFERENCE; CIRCADIAN-RHYTHMS; DIURNAL-VARIATION; STRESS; DISORDER; SPECTRUM; ADULTS;

D O I：

10.1007/s10803-012-1522-z

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

We examined daytime salivary cortisol and salivary alpha-amylase (sAA) secretion levels and variability in preschool-aged children with autism (AUT) and typically developing children (TYP). Fifty-two subjects (26 AUT and 26 TYP) were enrolled. Salivary samples were obtained at waking, midday, and bedtime on two consecutive days at three phases (baseline, 3 months later, 6 months later). There were modest increases in waking cortisol and sAA levels in AUT relative to TYP, but the increases were not statistically significant. Important differences were observed in cortisol and sAA variability between AUT and TYP. There was also a graded response among AUT by functional status-cortisol and sAA secretion levels were higher when IQ was lower.

引用

页码：2648 / 2658

页数：11

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