Contribution of capsule endoscopy to Peutz-Jeghers syndrome management in children

被引：22

作者：

Gastineau, Swellen ^{[1
]}

Viala, Jerome ^{[2
]}

Caldari, Dominique ^{[3
]}

Mas, Emmanuel ^{[4
]}

Darviot, Estelle ^{[5
]}

Le Gall, Catherine ^{[6
]}

Maurage, Chantal ^{[7
]}

Michaud, Laurent ^{[8
]}

Dabadie, Alain ^{[1
]}

机构：

[1] CHU Rennes, Dept Pediat, South Hosp, F-35203 Rennes, France

[2] CHU Robert Debre Hosp, Dept Pediat, Paris, France

[3] CHU Nantes, Dept Pediat, Mother Child Hosp, F-44035 Nantes 01, France

[4] CHU Toulouse, Dept Pediat, Childrens Hosp, Toulouse 9, France

[5] CHU Angers, Dept Pediat, Angers 01, France

[6] CHU Lyon, Dept Pediatrics, Woman Mother Child Hosp, Bron, France

[7] CHU Tours, Dept Pediat, CH Clocheville, Tours, France

[8] CHRU Lille, Dept Pediat, Jeanne de Flandre Hosp, Lille, France

来源：

DIGESTIVE AND LIVER DISEASE | 2012年 / 44卷 / 10期

关键词：

Capsule endoscopy; Child; Intussusception; Peutz-Jeghers syndrome; Polyp; SMALL-BOWEL POLYPS; PEDIATRIC-PATIENTS; RECOMMENDATIONS; CANCER; SURVEILLANCE; EXPERIENCE; RISK;

D O I：

10.1016/j.dld.2012.05.018

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Capsule endoscopy is recommended for children with Peutz-Jeghers syndrome as young as 8 years of age. Aim of our study was to evaluate the contribution of capsule endoscopy in managing risk of further obstructive complications. Methods: A retrospective analysis of 27 children who received at least 1 capsule endoscopy was conducted. Peutz-Jeghers syndrome was diagnosed based on the presence of an STK11 gene mutation or on the association of a hamartoma with 2 of 3 criteria (family history, mucocutaneous pigmentation, small bowel polyposis). Results: Thirty-seven capsule endoscopies were performed in 27 patients. The median age at first endoscopy was 11.4 years (range, 5.4-20.9). Jejunal polyps were found in 72% and ileal polyps in 55% of capsules. The original recommendations were followed 20/30 times. Three gastroscopies, 4 colonoscopies, 7 double balloon enteroscopies and 1 intra-operative enteroscopy were performed after the capsules. These procedures revealed jejunal polyps in 9/9 cases (8/9 resected) and ileal polyps in 3/5 (all resected). One intussusception occurred 8.4 months after the capsule endoscopy and required surgical resection. Conclusion: Capsule endoscopy is easily feasible in Peutz Jeghers syndrome, but the practice of systematic and repeated procedures needs to be validated prospectively. (C) 2012 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：839 / 843

页数：5

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