The Contribution of Angiogenesis to the Process of Metastasis

被引：399

作者：

Bielenberg, Diane R. ^{[1
]}

Zetter, Bruce R. ^{[1
]}

机构：

[1] Harvard Univ, Boston Childrens Hosp, Sch Med, Vasc Biol Program,Dept Surg, Boston, MA 02115 USA

来源：

CANCER JOURNAL | 2015年 / 21卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Angiogenesis; antiangiogenesis; cancer; EMT; endothelial cell; lymphangiogenesis; malignant; metastasis; tumor; vessel; ANTIANGIOGENIC THERAPY; TUMOR ANGIOGENESIS; SOIL HYPOTHESIS; BREAST-CANCER; LYMPH-NODE; MICROVASCULAR DENSITY; STROMAL FIBROBLASTS; MICROVESSEL DENSITY; ENDOTHELIAL-CELLS; BLOOD-VESSELS;

D O I：

10.1097/PPO.0000000000000138

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The role of angiogenesis in tumor growth has been studied continuously for over 45 years. It is now appreciated that angiogenesis is also essential for the dissemination and establishment of tumor metastases. In this review, we focus on the role of angiogenesis as a necessity for the escape of tumor cells into the bloodstream and for the establishment of metastatic colonies in secondary sites. We also discuss the role of tumor lymphangiogenesis as a means of dissemination of lymphatic metastases. Appropriate combination therapies may be used in the future to both prevent and treat metastatic disease through the rational use of antiangiogenic and antilymphangiogenic therapies in ways that are informed by the current and future work in the field.

引用

页码：267 / 273

页数：7

共 81 条

[1] Evading tumor evasion: Current concepts and perspectives of anti-angiogenic cancer therapy [J].

Abdollahi, Amir ;

Folkman, Judah .

DRUG RESISTANCE UPDATES, 2010, 13 (1-2) :16-28

[2] Matrigel cytometry: A novel method for quantifying angiogenesis in vivo [J].

Adini, A. ;

Fainaru, O. ;

Udagawa, T. ;

Connor, K. M. ;

Folkman, J. ;

D'Amato, R. J. .

JOURNAL OF IMMUNOLOGICAL METHODS, 2009, 342 (1-2) :78-81

[3] Antiangiogenic Therapy for Cancer: An Update [J].

Al-Husein, Belal ;

Abdalla, Maha ;

Trepte, Morgan ;

DeRemer, David L. ;

Somanath, Payaningal R. .

PHARMACOTHERAPY, 2012, 32 (12) :1095-1111

[4] Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis [J].

Al-Mehdi, AB ;

Tozawa, K ;

Fisher, AB ;

Shientag, L ;

Lee, A ;

Muschel, RJ .

NATURE MEDICINE, 2000, 6 (01) :100-102

[5] Targeting EGFR activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in VEGFR-2 dependence in tumor endothelial cells [J].

Amin, Dhara N. ;

Bielenberg, Diane R. ;

Lifshits, Eugene ;

Heymach, John V. ;

Klagsbrun, Michael .

MICROVASCULAR RESEARCH, 2008, 76 (01) :15-22

[6] Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to EGF and to EGFR kinase inhibitors [J].

Amin, DN ;

Hida, K ;

Bielenberg, DR ;

Klagsbrun, M .

CANCER RESEARCH, 2006, 66 (04) :2173-2180

[7] Functionally specialized junctions between endothelial cells of lymphatic vessels [J].

Baluk, Peter ;

Fuxe, Jonas ;

Hashizume, Hiroya ;

Romano, Talia ;

Lashnits, Erin ;

Butz, Stefan ;

Vestweber, Dietmar ;

Corada, Monica ;

Molendini, Cinzia ;

Dejana, Elisabetta ;

McDonald, Donald M. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (10) :2349-2362

[8] Effect of antiangiogenic therapy on slowly growing, poorly vascularized tumors in mice [J].

Beecken, WDC ;

Fernandez, A ;

Joussen, AM ;

Achilles, EG ;

Flynn, E ;

Lo, KM ;

Gillies, SD ;

Javaherian, K ;

Folkman, J ;

Shing, Y .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2001, 93 (05) :382-387

[9] Circulating tumor cell enumeration by the CellSearch system: The clinician's guide to breast cancer treatment? [J].

Beije, Nick ;

Jager, Agnes ;

Sleijfer, Stefan .

CANCER TREATMENT REVIEWS, 2015, 41 (02) :144-150

[10] INHIBITION OF CELL MOTILITY BY INTERFERON [J].

BROUTYBOYE, D ;

ZETTER, BR .

SCIENCE, 1980, 208 (4443) :516-518

← 1 2 3 4 5 6 7 8 9 →