CXCR4/CXCL12 in Non-Small-Cell Lung Cancer Metastasis to the Brain

被引：42

作者：

Cavallaro, Sebastiano ^{[1
]}

机构：

[1] Italian Natl Res Council, Funct Genom Ctr, Inst Neurol Sci, I-95125 Catania, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 01期

关键词：

brain metastases; chemokines; CXCL12; CXCR4; lung cancer; metastasis; PROPHYLACTIC CRANIAL IRRADIATION; CHEMOKINE RECEPTOR CXCR4; EPIDERMAL-GROWTH-FACTOR; MULTIMODALITY TREATMENT; FUNCTIONAL EXPRESSION; CEREBRAL METASTASES; SIGNAL-TRANSDUCTION; CXCL12/CXCR4; AXIS; BIOLOGICAL AXIS; PRIMARY TUMOR;

D O I：

10.3390/ijms14011713

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lung cancer represents the leading cause of cancer-related mortality throughout the world. Patients die of local progression, disseminated disease, or both. At least one third of the people with lung cancer develop brain metastases at some point during their disease, even often before the diagnosis of lung cancer is made. The high rate of brain metastasis makes lung cancer the most common type of tumor to spread to the brain. It is critical to understand the biologic basis of brain metastases to develop novel diagnostic and therapeutic approaches. This review will focus on the emerging data supporting the involvement of the chemokine CXCL12 and its receptor CXCR4 in the brain metastatic evolution of non-small-cell lung cancer (NSCLC) and the pharmacological tools that may be used to interfere with this signaling axis.

引用

页码：1713 / 1727

页数：15

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