Targeting transcription factors for therapeutic benefit

被引：34

作者：

Brennan, Paul ^{[1
]}

Donev, Rossen ^{[1
]}

Hewamana, Saman

机构：

[1] Cardiff Univ, Sch Med, Dept Med Biochem & Immunol, Cardiff CF14 4XN, S Glam, Wales

来源：

MOLECULAR BIOSYSTEMS | 2008年 / 4卷 / 09期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1039/b801920g

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcription factors are a. large class of biological molecules that are important for health and disease. Despite that there are challenges to targeting them therapeutically and most approaches alter their activity indirectly. Research at the chemical biology interface has led to the development of new ways of targeting transcription factors including blocking transcription factor dimerisation, targeting specific DNA sequences and DNA decoys. This review discusses these issues with a view to inspiring the development of new agents that could be useful for the treatment of cancer.

引用

页码：909 / 919

页数：11

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