Ca2+ activity signatures of myelin sheath formation and growth in vivo

被引：131
作者：
Baraban, Marion [1 ]
Koudelka, Sigrid [1 ]
Lyons, David A. [1 ]
机构：
[1] Univ Edinburgh, Ctr Neuroregenerat, Ctr Discovery Brain Sci, Edinburgh, Midlothian, Scotland
来源：
NATURE NEUROSCIENCE | 2018年 / 21卷 / 01期
基金：
英国惠康基金;
关键词：
SYNAPTIC VESICLE RELEASE; INDIVIDUAL OLIGODENDROCYTES; NEURONAL-ACTIVITY; NERVOUS-SYSTEM; AXONS; CALPASTATIN; PLASTICITY; ZEBRAFISH; INHIBITOR; CALPAINS;
D O I：
10.1038/s41593-017-0040-x
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
During myelination, individual oligodendrocytes initially overproduce short myelin sheaths, which are either retracted or stabilized. By live-imaging oligodendrocyte Ca2+ activity in vivo, we find that high-amplitude, long-duration Ca2+ transients in sheaths prefigure retractions, mediated by calpain. Following stabilization, myelin sheaths grow along axons, and we find that higher-frequency Ca2+ transient activity in sheaths precedes faster elongation. Our data implicate local Ca2+ signaling in regulating distinct stages of myelination.
引用
收藏
页码：19 / +
页数：7
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