The complexities and challenges of preventing and treating nontuberculous mycobacterial diseases

被引：102
作者：
Baldwin, Susan L. [1 ]
Larsen, Sasha E. [1 ,2 ]
Ordway, Diane [3 ]
Cassell, Gail [1 ,4 ]
Coler, Rhea N. [1 ,2 ,5 ]
机构：
[1] Infect Dis Res Inst, Seattle, WA 98102 USA
[2] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA
[3] Colorado State Univ, Dept Microbiol Immunol & Pathol, Mycobacteria Res Labs, Ft Collins, CO 80523 USA
[4] Harvard Med Sch, Dept Global Hlth & Social Med, Boston, MA 02115 USA
[5] PAI Life Sci, Seattle, WA 98102 USA
来源：
PLOS NEGLECTED TROPICAL DISEASES | 2019年 / 13卷 / 02期
基金：
美国国家卫生研究院;
关键词：
HIV-NEGATIVE PATIENTS; NECROSIS-FACTOR-ALPHA; RIBOSOMAL-RNA GENE; AVIUM COMPLEX; PULMONARY-DISEASE; LUNG-DISEASE; CLARITHROMYCIN RESISTANCE; TREATMENT OUTCOMES; VACCINE CANDIDATE; CYSTIC-FIBROSIS;
D O I：
10.1371/journal.pntd.0007083
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Seemingly innocuous nontuberculous mycobacteria (NTM) species, classified by their slow or rapid growth rates, can cause a wide range of illnesses, from skin ulceration to severe pulmonary and disseminated disease. Despite their worldwide prevalence and significant disease burden, NTM do not garner the same financial or research focus as Mycobacterium tuberculosis. In this review, we outline the most abundant of over 170 NTM species and inadequacies of diagnostics and treatments and weigh the advantages and disadvantages of currently available in vivo animal models of NTM. In order to effectively combat this group of mycobacteria, more research focused on appropriate animal models of infection, screening of chemotherapeutic compounds, and development of anti-NTM vaccines and diagnostics is urgently needed.
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页数：23
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