Tumor-specific activation of prodrugs: is there a role for nuclear medicine?

被引:2
作者
Antunes, Ines F. [1 ]
Haisma, Hidde J. [2 ]
de Vries, Erik F. J. [1 ]
机构
[1] Univ Med Ctr Groningen, Dept Nucl Med & Mol Imaging, NL-9713 GZ Groningen, Netherlands
[2] Univ Groningen, Univ Ctr Pharm, Dept Therapeut Gene Modulat, Groningen, Netherlands
关键词
D O I
10.1097/MNM.0b013e3283094efc
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
引用
收藏
页码:845 / 846
页数:2
相关论文
共 21 条
[1]   Radiolabelled tracers and anticancer drugs for assessment of therapeutic efficacy using PET [J].
Brady, F ;
Luthra, SK ;
Brown, GD ;
Osman, S ;
Aboagye, E ;
Saleem, A ;
Price, PM .
CURRENT PHARMACEUTICAL DESIGN, 2001, 7 (18) :1863-1892
[2]  
Chen Xi, 2003, Current Medicinal Chemistry - Anti-Cancer Agents, V3, P139, DOI 10.2174/1568011033353470
[3]  
Dachs GU, 1997, ONCOL RES, V9, P313
[4]   Pronounced antitumor efficacy by extracellular activation of a doxorubicin-glucuronide prodrug after adenoviral vector-mediated expression of a human antibody-enzyme fusion protein [J].
De Graaf, M ;
Pinedo, HM ;
Oosterhoff, D ;
Van der Meulen-Muileman, IH ;
Gerritsen, WR ;
Haisma, HJ ;
Boven, E .
HUMAN GENE THERAPY, 2004, 15 (03) :229-238
[5]  
de Graaf M, 2002, CURR PHARM DESIGN, V8, P1391
[6]  
de Groot FMH, 2001, CURR MED CHEM, V8, P1093
[7]   Scintigraphic imaging of HSVtk gene therapy [J].
de Vries, EFJ ;
Buursma, AR ;
Hospers, GAP ;
Mulder, NH ;
Vaalburg, W .
CURRENT PHARMACEUTICAL DESIGN, 2002, 8 (16) :1435-1450
[8]   A gadolinium chelate for detection of β-glucuronidase:: A self-immolative approach [J].
Duimstra, JA ;
Femia, FJ ;
Meade, TJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (37) :12847-12855
[9]  
Greco O, 2001, J CELL PHYSIOL, V187, P22, DOI 10.1002/1097-4652(2001)9999:9999<::AID-JCP1060>3.0.CO
[10]  
2-H