ProfCom: a web tool for profiling the complex functionality of gene groups identified from high-throughput data

被引：58

作者：

Antonov, Alexey V. ^{[2
]}

Schmidt, Thorsten ^{[1
]}

Wang, Yu ^{[2
]}

Mewes, Hans W. ^{[1
,2
]}

机构：

[1] Tech Univ Munich, Wissensch Zentrum Weihenstephan, Dept Genome Oriented Bioinformat, D-85350 Freising Weihenstephan, Germany

[2] Helmholtz Zentrum Munich, Natl Res Ctr Environm & Hlth, Inst Bioinformat, D-85764 Neuherberg, Germany

来源：

NUCLEIC ACIDS RESEARCH | 2008年 / 36卷

关键词：

D O I：

10.1093/nar/gkn239

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ProfCom is a web-based tool for the functional interpretation of a gene list that was identified to be related by experiments. A trait which makes ProfCom a unique tool is an ability to profile enrichments of not only available Gene Ontology (GO) terms but also of complex functions. A Complex function is constructed as Boolean combination of available GO terms. The complex functions inferred by ProfCom are more specific in comparison to single terms and describe more accurately the functional role of genes. ProfCom provides a user friendly dialog-driven web page submission available for several model organisms and supports most available gene identifiers. In addition, the web service interface allows the submission of any kind of annotation data. ProfCom is freely available at http://webclu.bio.wzw.tum.de/profcom/.

引用

页码：W347 / W351

页数：5

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