Antiangiogenic properties of cafestol, a coffee diterpene, in human umbilical vein endothelial cells

被引：34

作者：

Wang, Shuaiyu ^{[1
,2
]}

Yoon, Yeo Cho ^{[1
]}

Sung, Mi-Jeong ^{[1
]}

Hur, Haeng-Jeon ^{[1
]}

Park, Jae-Ho ^{[1
]}

机构：

[1] Korea Food Res Inst, Songnam 463746, Kyungki Do, South Korea

[2] Univ Sci & Technol, Taejon 305333, South Korea

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2012年 / 421卷 / 03期

关键词：

Angiogenesis; Cafestol; FAK; Akt; Nitric oxide; FOCAL ADHESION KINASE; NITRIC-OXIDE SYNTHASE; TUMOR ANGIOGENESIS; AKT; PHOSPHORYLATION; ACTIVATION; KAHWEOL; CANCER; SIGNAL; MIGRATION;

D O I：

10.1016/j.bbrc.2012.04.046

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As angiogenesis plays important roles in tumor growth and metastasis, searching for antiangiogenic compounds is a promising tactic for treating cancers. Cafestol, a diterpene found mainly in unfiltered coffee, provides benefit through varied biological activity, including antitumorigenic, antioxidative, and anti-inflammatory effects. This study aimed to investigate the effects of cafestol on angiogenesis and to uncover the associated mechanism. We show that cafestol inhibits angiogenesis of human umbilical vascular endothelial cells. This inhibition affects the following specific steps of the angiogenic process: proliferation, migration, and tube formation. The inhibitory effects of cafestol are accompanied by decreasing phosphorylation of FAK and Akt and by a decrease in nitric oxide production. Overall, cafestol inhibits angiogenesis by affecting the angiogenic signaling pathway. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：567 / 571

页数：5

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