Antiangiogenic properties of cafestol, a coffee diterpene, in human umbilical vein endothelial cells

被引：33
作者：
Wang, Shuaiyu [1 ,2 ]
Yoon, Yeo Cho [1 ]
Sung, Mi-Jeong [1 ]
Hur, Haeng-Jeon [1 ]
Park, Jae-Ho [1 ]
机构：
[1] Korea Food Res Inst, Songnam 463746, Kyungki Do, South Korea
[2] Univ Sci & Technol, Taejon 305333, South Korea
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2012年 / 421卷 / 03期
关键词：
Angiogenesis; Cafestol; FAK; Akt; Nitric oxide; FOCAL ADHESION KINASE; NITRIC-OXIDE SYNTHASE; TUMOR ANGIOGENESIS; AKT; PHOSPHORYLATION; ACTIVATION; KAHWEOL; CANCER; SIGNAL; MIGRATION;
D O I：
10.1016/j.bbrc.2012.04.046
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
As angiogenesis plays important roles in tumor growth and metastasis, searching for antiangiogenic compounds is a promising tactic for treating cancers. Cafestol, a diterpene found mainly in unfiltered coffee, provides benefit through varied biological activity, including antitumorigenic, antioxidative, and anti-inflammatory effects. This study aimed to investigate the effects of cafestol on angiogenesis and to uncover the associated mechanism. We show that cafestol inhibits angiogenesis of human umbilical vascular endothelial cells. This inhibition affects the following specific steps of the angiogenic process: proliferation, migration, and tube formation. The inhibitory effects of cafestol are accompanied by decreasing phosphorylation of FAK and Akt and by a decrease in nitric oxide production. Overall, cafestol inhibits angiogenesis by affecting the angiogenic signaling pathway. (C) 2012 Elsevier Inc. All rights reserved.
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收藏
页码：567 / 571
页数：5
相关论文
共 24 条
  • [1] Challenges of antiangiogenic cancer therapy:: trials and errors, and renewed hope
    Angel Medina, Miguel
    Munoz-Chapuli, Ramon
    Quesada, Ana R.
    [J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2007, 11 (03) : 374 - 382
  • [2] Angiogenesis in cancer and other diseases
    Carmeliet, P
    Jain, RK
    [J]. NATURE, 2000, 407 (6801) : 249 - 257
  • [3] Molecular mechanisms and clinical applications of angiogenesis
    Carmeliet, Peter
    Jain, Rakesh K.
    [J]. NATURE, 2011, 473 (7347) : 298 - 307
  • [4] Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity
    Cavin, C
    Holzhaeuser, D
    Scharf, G
    Constable, A
    Huber, WW
    Schilter, B
    [J]. FOOD AND CHEMICAL TOXICOLOGY, 2002, 40 (08) : 1155 - 1163
  • [5] Angiogenesis Inhibitors: Current Strategies and Future Prospects
    Cook, Kristina M.
    Figg, William D.
    [J]. CA-A CANCER JOURNAL FOR CLINICIANS, 2010, 60 (04) : 222 - 243
  • [6] Phosphorylation of the endothelial nitric oxide synthase at Ser-1177 is required for VEGF-induced endothelial cell migration
    Dimmeler, S
    Dernbach, E
    Zeiher, AM
    [J]. FEBS LETTERS, 2000, 477 (03) : 258 - 262
  • [7] Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    Dimmeler, S
    Fleming, I
    Fisslthaler, B
    Hermann, C
    Busse, R
    Zeiher, AM
    [J]. NATURE, 1999, 399 (6736) : 601 - 605
  • [8] The biology of VEGF and its receptors
    Ferrara, N
    Gerber, HP
    LeCouter, J
    [J]. NATURE MEDICINE, 2003, 9 (06) : 669 - 676
  • [9] Angiogenesis as a therapeutic target
    Ferrara, N
    Kerbel, RS
    [J]. NATURE, 2005, 438 (7070) : 967 - 974
  • [10] Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
    Fulton, D
    Gratton, JP
    McCabe, TJ
    Fontana, J
    Fujio, Y
    Walsh, K
    Franke, TF
    Papapetropoulos, A
    Sessa, WC
    [J]. NATURE, 1999, 399 (6736) : 597 - 601
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