In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia™) as a potential nerve agent bioscavenger

被引:69
作者
Cerasoli, DM
Griffiths, EM
Doctor, BP
Saxena, A
Fedorko, JM
Greig, NH
Yu, QS
Huang, Y
Wilgus, H
Karatzas, CN
Koplovitz, I
Lenz, DE
机构
[1] USAMRICD, Div Pharmacol, Aberdeen Proving Ground, MD 21010 USA
[2] WRAIR, Div Biochem, Silver Spring, MD 20910 USA
[3] NIA, Drug Design & Dev Sect, Baltimore, MD 21224 USA
[4] Nexia Biotechnol Inc, Vaudreuil Dorion, PQ J7V 8P5, Canada
关键词
organophosphorus nerve agent; butyrylcholinesterase; bioscavenger; recombinant;
D O I
10.1016/j.cbi.2005.10.052
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
07
引用
收藏
页码:363 / 365
页数:3
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