Effect of paternal age on human sperm chromosomes

被引：79
作者：
Sartorelli, EMP [1 ]
Mazzucatto, LF [1 ]
de Pina-Neto, JM [1 ]
机构：
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Genet, Sao Paulo, Brazil
来源：
FERTILITY AND STERILITY | 2001年 / 76卷 / 06期
基金：
巴西圣保罗研究基金会;
关键词：
cytogenetics; human spermatozoa; chromosomal aberrations;
D O I：
10.1016/S0015-0282(01)02894-1
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To investigate whether increased age alters the frequency and type of chromosomal anomalies in human spermatozoa. Design: Semen specimens were collected from donors via masturbation; cytogenetic studies were performed on sperm chromosomes after heterologous (human-hamster) in vitro fertilization. Setting: Cytogenetics Laboratory, Genetics Department, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil. Patients(s): Seven men ages 59-74 (older group) and five men ages 23-39 (control group). Main Outcome Measure(s): Frequency and types of chromosomal anomalies in older and control group donors. Result(s): The frequency of numerical and structural aberrations (acentric fragments and complex radial figures) was significantly greater in chromosomes of older donors when compared with those of the control group. Conclusion(s): The higher frequency of sperm chromosome aberrations in older men was mainly a result of increased nondisjunction, acentric fragments, and complex radial figures. (Fertil Steril (R) 2001;76:1119-23. (C) 2001 by American Society for Reproductive Medicine.).
引用
收藏
页码：1119 / 1123
页数：5
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