Dietary changes and cognition over 2 years within a multidomain intervention trial-The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

被引:63
作者
Lehtisalo, Jenni [1 ,2 ]
Levlahti, Esko [1 ]
Lindstrom, Jaana [1 ]
Hanninen, Tuomo [3 ]
Paajanen, Teemu [4 ]
Peltonen, Markku [1 ]
Antikainen, Riitta [5 ,6 ,7 ]
Laatikainen, Tiina [1 ,8 ,9 ]
Strandberg, Timo [5 ,10 ,11 ]
Soininen, Hilkka [3 ,12 ]
Tuomilehto, Jaakko [1 ,13 ,14 ,15 ,16 ]
Kivipelto, Miia [1 ,17 ,18 ,19 ,20 ]
Ngandu, Tiia [1 ,17 ]
机构
[1] Natl Inst Hlth & Welf, Publ Hlth Promot Unit, Dept Publ Hlth Solut, Helsinki, Finland
[2] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland
[3] Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland
[4] Finnish Inst Occupat Hlth, Res & Serv Ctr Occupat Hlth, Helsinki, Finland
[5] Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland
[6] Oulu Univ Hosp, Med Res Ctr Oulu, Oulu, Finland
[7] Oulu City Hosp, Oulu, Finland
[8] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland
[9] Joint Municipal Author North Karelia Social & Hlt, Joensuu, Finland
[10] Univ Helsinki, Clinicum, Helsinki, Finland
[11] Helsinki Univ Hosp, Helsinki, Finland
[12] Univ Eastern Finland, Inst Clin Med, Dept Neurol, Kuopio, Finland
[13] South Ostrobothnia Cent Hosp, Seinajoki, Finland
[14] Danube Univ Krems, Dept Clin Neurosci & Prevent Med, Krems, Austria
[15] King Abdulaziz Univ, Diabet Res Grp, Jeddah, Saudi Arabia
[16] Dasman Diabet Inst, Kuwait, Kuwait
[17] Karolinska Inst, Div Clin Geriatr, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc NVS, Huddinge, Sweden
[18] Karolinska Inst, Aging Res Ctr, Stockholm, Sweden
[19] Stockholm Univ, Stockholm, Sweden
[20] Imperial Coll London, Sch Publ Hlth, Neuroepidemiol & Ageing Res Unit, London, England
基金
芬兰科学院; 瑞典研究理事会;
关键词
Diet; Cognitive performance; Prevention; Older adults; Growth curve analysis; BASE-LINE CHARACTERISTICS; LIFE-STYLE INTERVENTION; STOP HYPERTENSION DIET; ALZHEIMERS-DISEASE; MEDITERRANEAN DIET; OLDER-ADULTS; DECLINE; DEMENTIA; PATTERNS; RISK;
D O I
10.1016/j.jalz.2018.10.001
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Introduction: Association between healthy diet and better cognition is well established, but evidence is limited to evaluate the effect of dietary changes adopted in older age. Methods: We investigated the role of dietary changes in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) with 1260 at-risk participants (60-77 years) who were randomized to intensive multidomain intervention (including dietary counseling) or regular health advice for 2 years. Parallel process latent growth curves of adherence to dietary recommendations and cognitive performance were analyzed. Results: Adherence to healthy diet at baseline predicted improvement in global cognition, regardless of intervention allocation (P = .003). Dietary improvement was associated with beneficial changes in executive function, especially in the intervention group (P = .008; P = .051 for groups combined). Discussion: Dietary changes initiated during the intervention were related to changes in executive function in 2 years. Long-term diet appeared more influential for global cognition. (C) 2018 The Authors. Published by Elsevier Inc.
引用
收藏
页码:410 / 417
页数:8
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