Moderate decline in select synaptic markers in the prefrontal cortex (BA9) of patients with Alzheimer's disease at various cognitive stages

被引：51

作者：

Poirel, Odile ^{[1
]}

Mella, Sebastien ^{[1
]}

Videau, Catherine ^{[2
]}

Ramet, Lauriane ^{[1
]}

Davoli, Maria Antonietta ^{[3
]}

Herzog, Etienne ^{[1
,6
]}

Katsel, Pavel ^{[4
]}

Mechawar, Naguib ^{[3
]}

Haroutunian, Vahram ^{[4
]}

Epelbaum, Jacques ^{[2
,5
]}

Daumas, Stephanie ^{[1
]}

El Mestikawy, Salah ^{[1
,3
]}

机构：

[1] UPMC Univ Paris 06, Sorbonne Univ, CNRS,NPS,IBPS, INSERM,Neurosci Paris Seine,Inst Biol Paris Seine, F-75005 Paris, France

[2] Univ Paris 05, Ctr Psychiat & Neurosci, Univ Sorbonne Paris Cite, INSERM,UMR S894, F-75014 Paris, France

[3] McGill Univ, Dept Psychiat, Douglas Hosp, Res Ctr, 6875 Blvd Lasalle Verdun, Quebec City, PQ, Canada

[4] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA

[5] CNRS, UMR 7179, MECADEV, Museum Natl Hist Nat, F-91800 Brunoy, France

[6] Univ Bordeaux, CNRS, IINS, UMR 5297, F-33000 Bordeaux, France

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

关键词：

VESICULAR GLUTAMATE TRANSPORTERS; LONG-TERM POTENTIATION; A-BETA OLIGOMERS; FRONTAL-CORTEX; VGLUT1; PATHOLOGY; EXPRESSION; DEFICITS; IMPAIRMENT; ACCUMULATION;

D O I：

10.1038/s41598-018-19154-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Synaptic loss, plaques and neurofibrillary tangles are viewed as hallmarks of Alzheimer's disease (AD). This study investigated synaptic markers in neocortical Brodmann area 9 (BA9) samples from 171 subjects with and without AD at different levels of cognitive impairment. The expression levels of vesicular glutamate transporters (VGLUT1&2), glutamate uptake site (EAAT2), post-synaptic density protein of 95 kD (PSD95), vesicular GABA/glycine transporter (VIAAT), somatostatin (som), synaptophysin and choline acetyl transferase (ChAT) were evaluated. VGLUT2 and EAAT2 were unaffected by dementia. The VGLUT1, PSD95, VIAAT, som, ChAT and synaptophysin expression levels significantly decreased as dementia progressed. The maximal decrease varied between 12% (synaptophysin) and 42% (som). VGLUT1 was more strongly correlated with dementia than all of the other markers (polyserial correlation = -0.41). Principal component analysis using these markers was unable to differentiate the CDR groups from one another. Therefore, the status of the major synaptic markers in BA9 does not seem to be linked to the cognitive status of AD patients. The findings of this study suggest that the loss of synaptic markers in BA9 is a late event that is only weakly related to AD dementia.

引用

页数：14

共 87 条

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