Functionalising the azobenzene motif delivers a light-responsive membrane-interactive compound with the potential for photodynamic therapy applications

被引：17

作者：

Hester, Theodore J. ^{[1
]}

Dennison, Sarah R. ^{[2
]}

Baker, Matthew J. ^{[3
]}

Snape, Timothy J. ^{[2
]}

机构：

[1] Univ Cent Lancashire, Sch Forens & Invest Sci, Preston PR1 2HE, Lancs, England

[2] Univ Cent Lancashire, Sch Pharm & Biomed Sci, Preston PR1 2HE, Lancs, England

[3] Univ Strathclyde, Dept Pure & Appl Chem, WestCHEM, Glasgow G1 1XL, Lanark, Scotland

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 29期

关键词：

HOST-DEFENSE PEPTIDES; HEADGROUP;

D O I：

10.1039/c5ob00465a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

When adorned with n-octyl chains azobenzene is able to disrupt a variety of calcein-loaded phospholipid liposomes. The levels of lysis observed are dependent both on the lipid headgroup and the conformation of the azobenzene compound. In all cases studied, it has been shown that the cis-conformer is more membrane-interactive than the trans-conformer, suggesting that this class of molecule could be optimised for photo-dynamic therapy applications against infectious pathogens.

引用

页码：8067 / 8070

页数：4

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