Targeting virulence: A new paradigm for antifungals

被引：136

作者：

Gauwerky, Katharina ^{[1
]}

Borelli, Claudia ^{[1
]}

Korting, Hans C. ^{[1
]}

机构：

[1] Univ Munich, Dept Dermatol & Allergol, D-80337 Munich, Germany

来源：

DRUG DISCOVERY TODAY | 2009年 / 14卷 / 3-4期

关键词：

HIV-INFECTED PATIENTS; SECRETED ASPARTYL PROTEINASES; IN-VITRO ANTIFUNGAL; CANDIDA-ALBICANS; CRYPTOCOCCUS-NEOFORMANS; ASPERGILLUS-FUMIGATUS; ORAL CANDIDOSIS; SUBINHIBITORY CONCENTRATIONS; VAGINAL CANDIDIASIS; BACTERIAL VIRULENCE;

D O I：

10.1016/j.drudis.2008.11.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the recent past, we have found ourselves in need of truly novel antifungal drugs as drug resistance in fungi has been evolving. Moreover, effective therapy has become particularly important as the number of immuno-compromised patients with life-threatening fungal infections increases. Fortunately, during the last few years, virulence factors of fungi and their inhibitors have, at least to some extent, been discovered and characterized. This should provide new options for the development of potential antifungal therapeutics. Inhibitors of the secreted aspartic proteinase of Candida albicans might turn out to be particularly rewarding.

引用

页码：214 / 222

页数：9

共 71 条

[1]

AbadZapatero C, 1996, PROTEIN SCI, V5, P640

[2] Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions [J].

Albrecht, A ;

Felk, A ;

Pichova, I ;

Naglik, JR ;

Schaller, M ;

de Groot, P ;

MacCallum, D ;

Odds, FC ;

Schäfer, W ;

Klis, F ;

Monod, M ;

Hube, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (02) :688-694

[3]

Alekshun MN., 2004, DRUG DISCOV TODAY TH, V1, P483, DOI DOI 10.1016/J.DDSTR.2004.10.006

[4] Bacterial virulence as a target for antimicrobial chemotherapy [J].

Alksne, LE ;

Projan, SJ .

CURRENT OPINION IN BIOTECHNOLOGY, 2000, 11 (06) :625-636

[5] Exposure to therapeutic concentrations of ritonavir, but not saquinavir, reduces secreted aspartyl proteinase of Candida parapsilosis [J].

Asencio, MA ;

Garduño, E ;

Pérez-Giraldo, C ;

Blanco, MT ;

Hurtado, C ;

Gómez-García, AC .

CHEMOTHERAPY, 2005, 51 (05) :252-255

[6] How bacteria talk to each other: regulation of gene expression by quorum sensing [J].

Bassler, BL .

CURRENT OPINION IN MICROBIOLOGY, 1999, 2 (06) :582-587

[7] In vitro antifungal, and anti-elastase activity of some aliphatic aldehydes from Olea europaea L. fruit [J].

Battinelli, L. ;

Daniele, C. ;

Cristiani, M. ;

Bisignano, G. ;

Saija, A. ;

Mazzanti, G. .

PHYTOMEDICINE, 2006, 13 (08) :558-563

[8] Evidence of multiple extracellular phospholipase activities of Aspergillus fumigatus [J].

Birch, M ;

Robson, G ;

Law, D ;

Denning, DW .

INFECTION AND IMMUNITY, 1996, 64 (03) :751-755

[9] Calcineurin is essential for Candida albicans survival in serum and virulence [J].

Blankenship, JR ;

Wormley, FL ;

Boyce, MK ;

Schell, WA ;

Filler, SG ;

Perfect, JR ;

Heitman, J .

EUKARYOTIC CELL, 2003, 2 (03) :422-430

[10] X-ray structures of Sap 1 and Sap5:: Structural comparison of the secreted aspartic proteinases from Candida albicans [J].

Borelli, Claudia ;

Ruge, Elisabeth ;

Lee, Jung Hoon ;

Schaller, Martin ;

Vogelsang, Alexandra ;

Monod, Michel ;

Korting, Hans Christian ;

Huber, Robert ;

Maskos, Klaus .

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2008, 72 (04) :1308-1319

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