Prenatal stress and elevated seizure susceptibility: Molecular inheritable changes

被引：8

作者：

Saboory, Ehsan ^{[1
]}

Mohammadi, Sedra ^{[2
]}

Dindarian, Sina ^{[2
]}

Mohammadi, Hozan ^{[3
]}

机构：

[1] Urmia Univ Med Sci, Neurophysiol Res Ctr, Orumiyeh, Iran

[2] Urmia Univ Med Sci, Student Res Comm, Orumiyeh, Iran

[3] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

来源：

EPILEPSY & BEHAVIOR | 2019年 / 96卷

关键词：

Prenatal stress; Early-life stages; Seizure; Epilepsy; Long-lasting outcomes; EARLY-LIFE STRESS; MESSENGER-RNA EXPRESSION; MATERNAL STRESS; SOCIAL STRESS; NOREPINEPHRINE TRANSPORTER; RAT HIPPOCAMPUS; GLUCOCORTICOID-RECEPTORS; PROGRAMS NEUROENDOCRINE; CELL-PROLIFERATION; GABA(A) RECEPTORS;

D O I：

10.1016/j.yebeh.2019.04.046

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Stressful episodes are common during early-life and may have a wide range of negative effects on both physical and mental status of the offspring. In addition to various neurobehavioral complications induced by prenatal stress (PS), seizure is a common complication with no fully explained cause. In this study, the association between PS and seizure susceptibility was reviewed focusing on sex differences and various underlying mechanisms. The role of drugs in the initiation of seizure and the effects of PS on the nervous system that prone the brain for seizure, especially the hypothalamic-pituitary-adrenal (HPA) axis, are also discussed in detail by reviewing the papers studying the effect of PS on glutamatergic, gamma-aminobutyric acid (GABA)ergic, and adrenergic systems in the context of seizure and epilepsy. Finally, epigenetic changes in epilepsy are described, and the underlying mechanisms of this change are expanded. As the effects of PS may be life-lasting, it is possible to prevent future psychiatric and behavioral disorders including epilepsy by preventing avoidable PS risk factors. (C) 2019 Published by Elsevier Inc.

引用

页码：122 / 131

页数：10

共 193 条

[1] Prenatal psychological stress causes higher emotionality, depression-like behavior, and elevated activity in the hypothalamo-pituitary-adrenal axis [J].