Loss of orphan nuclear receptor GCNF function disrupts forebrain development and the establishment of the isthmic organizer

被引：22
作者：
Chung, ACK
Xu, XP
Niederreither, KA
Cooney, AJ
机构：
[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA
[2] Baylor Coll Med, Ctr Cardiovasc Dev, Dept Med, Houston, TX 77030 USA
来源：
DEVELOPMENTAL BIOLOGY | 2006年 / 293卷 / 01期
关键词：
nuclear receptor; GCNF; isthmic organizer; midbrain-hindbrain boundary;
D O I：
10.1016/j.ydbio.2005.12.017
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The isthmic organizer, which is located at the midbrain-hindbrain boundary, is important for midbrain development. The mechanism by which the development of the organizer is initiated and maintained is not well understood. Inactivation of the gene encoding the orphan nuclear receptor, GCNF, diminishes the expression of secreted signaling molecules, Fgf8 and Wnt1, the paired box genes Pax2/5, En1/2, and homeodomain transcription factor Gbx2; all of which are essential for isthmic organizer function. In addition, full neuronal differentiation is not observed in the midbrain region of GCNF(-/-) embryos. Increased cell death may contribute to the loss of midbrain structure in GCNF(-/-) embryos. These results indicate that GCNF is required for establishment of the isthmic organizer, thereby regulating the midbrain development. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：13 / 24
页数：12
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