1,3-Dipolar cycloaddition of stabilised and non-stabilised azomethine ylides derived from uracil polyoxin C (UPoC): access to nikkomycin analogues

被引：53

作者：

Dondas, HA

Fishwick, CWG

Grigg, R ^{[1
]}

Kilner, C

机构：

[1] Univ Leeds, Dept Chem, MIDAS, Leeds LS2 9JT, W Yorkshire, England

[2] Mersin Univ, Fac Pharm, Dept Chem, Mersin, Turkey

来源：

TETRAHEDRON | 2004年 / 60卷 / 15期

关键词：

uracil polyoxin C; Nikkomycin; azomethine ylide; 1,3-dipolar cycloaddition; chitin synthetase inhibitors; decarboxylative cycloaddition; semi-empirical; calculations;

D O I：

10.1016/j.tet.2004.02.028

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cascade thermal and decarboxylative cycloaddition reactions of uracil polyoxin C (UPoC) with mono- and di-carbonyl compounds in the presence of a dipolarophile leads, via stabilised and non-stabilised azomethine ylides respectively, to a series of polyoxin cycloadducts related to Nikkomycin B in good to excellent yields and high diastereoselectivity. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3473 / 3485

页数：13

共 30 条

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